Retrospective Data Analysis of the Influence of Age and Sex on TPMT Activity and Its Phenotype-Genotype Correlation.
Journal:
The journal of applied laboratory medicine
PMID:
31639757
Abstract
BACKGROUND: Therapeutic efficacy and toxicity of thiopurine drugs (used as anticancer and immunosuppressant agents) are affected by thiopurine S-methyltransferase (TPMT) enzyme activity. genotype and/or phenotype is used to predict the risk for adverse effects before drug administration. Inosine triphosphate pyrophosphatase (ITPA) is another enzyme involved in thiopurine metabolism. In this study, we aimed to evaluate () frequency of various TPMT phenotypes and genotypes, () correlations between them, () influence of age and sex on TPMT activity, and () distribution of variants among various TPMT subgroups.