Elevated Coronary Artery Calcium Quantified by a Validated Deep Learning Model From Lung Cancer Radiotherapy Planning Scans Predicts Mortality.

Journal: JCO clinical cancer informatics
Published Date: Jan 1, 2022

Abstract

PURPOSE: Coronary artery calcium (CAC) quantified on computed tomography (CT) scans is a robust predictor of atherosclerotic coronary disease; however, the feasibility and relevance of quantitating CAC from lung cancer radiotherapy planning CT scans is unknown. We used a previously validated deep learning (DL) model to assess whether CAC is a predictor of all-cause mortality and major adverse cardiac events (MACEs).

Authors

  • Katelyn M Atkins
    Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Jakob Weiss
    Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
  • Roman Zeleznik
    Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Danielle S Bitterman
    Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.
  • Tafadzwa L Chaunzwa
    Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA. tafadzwa_chaunzwa@dfci.harvard.edu.
  • Elizabeth Huynh
    Artificial Intelligence in Medicine (AIM) Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Christian Guthier
    Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • David E Kozono
    Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA.
  • John H Lewis
    Department of Radiation Oncology, University of California, Los Angeles, 200 Suite B265, Medical Plaza Driveway, Los Angeles, 90095, CA, USA.
  • Balaji K Tamarappoo
  • Anju Nohria
    Department of Cardiovascular Medicine, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA.
  • Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, Boston.
  • Hugo J W L Aerts
    Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.
  • Raymond H Mak
    Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.

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