AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens.

Journal: BMC genomics
Published Date: Jan 25, 2022

Abstract

BACKGROUND: Antibiotic resistance is a growing global health concern prompting researchers to seek alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) are attracting attention again as therapeutic agents with promising utility in this domain, and using in silico methods to discover novel AMPs is a strategy that is gaining interest. Such methods can sift through large volumes of candidate sequences and reduce lab screening costs.

Authors

  • Chenkai Li
    Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada.
  • Darcy Sutherland
    Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada.
  • S Austin Hammond
    Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada.
  • Chen Yang
    Department of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.
  • Figali Taho
    Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, V5Z 4S6, Canada.
  • Lauren Bergman
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C3, Canada.
  • Simon Houston
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C3, Canada.
  • Rene L Warren
  • Titus Wong
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
  • Linda M N Hoang
    Public Health Laboratory, British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada.
  • Caroline E Cameron
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C3, Canada.
  • Caren C Helbing
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8P 5C3, Canada.
  • Inanc Birol

Keywords

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