Proceedings of the National Academy of Sciences of the United States of America
Jan 8, 2026
Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus hampering antiviral responses. CD8 T cell populations are reduced, the level of which has emerged as a...
Journal of chemical information and modeling
Dec 23, 2025
Antimicrobial peptides have emerged as a potential alternative to traditional small-molecule antimicrobials. They possess broad-spectrum efficacy and increasingly confront the challenges of bacterial resistance, especially the adaptive resistance of ...
World journal of microbiology & biotechnology
Nov 18, 2025
There is a growing concern about fungal infections and antifungal resistance among fungal species, underscoring the need for finding alternative treatments. Antifungal peptides (AFPs) are interesting and promising candidates for developing novel anti...
Journal of chemical information and modeling
Nov 6, 2025
Increasing concerns regarding prolonged antibiotic usage have spurred the search for alternative treatments. Antimicrobial peptides (AMPs), first discovered in the 1980s, have exhibited significant potential against a broad range of bacteria. Short-s...
Marine biotechnology (New York, N.Y.)
Oct 30, 2025
Antimicrobial resistance is a serious threat to global public health and requires new therapeutic approaches. Antimicrobial peptides (AMP) are recognized as promising candidates to address antimicrobial resistance. AMP can disrupt cell membranes by i...
Deep learning models show promise in accelerating the design and optimization of antimicrobial peptides (AMPs), but current methods face challenges, such as low success rates, or large virtual library scales. In this study, we introduce DLFea4AMPGen,...
Extended-spectrum β-lactamases in Escherichia coli poses a significant threat for clinicians in tertiary healthcare settings, rendering treatments ineffective with newer β-lactam-β-lactamase inhibitors combinations. To overcome this, the present stud...
Journal of chemical information and modeling
Sep 17, 2025
The escalating issue of antibiotic resistance has created an urgent global demand within the biomedical field for the discovery of novel antimicrobial molecules as alternatives to traditional antibiotics. Previous studies have reported the identifica...
Journal of chemical information and modeling
Aug 29, 2025
Antimicrobial Peptides (AMPs) are a promising strategy to address bacterial resistance, yet only a limited number have advanced to clinical trials. Recent advances in deep learning provide new opportunities for AMP design. Here, we propose an integra...
Salmonella enterica serovar Typhi (S. Typhi) is a strictly human-restricted Gram-negative pathogen and the causative agent of typhoid fever, a major global health concern. Current treatment relies heavily on antibiotics, however, the rapid emergence ...
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