Interpretable deep learning approach for oral cancer classification using guided attention inference network.

Journal: Journal of biomedical optics
Published Date:

Abstract

SIGNIFICANCE: Convolutional neural networks (CNNs) show the potential for automated classification of different cancer lesions. However, their lack of interpretability and explainability makes CNNs less than understandable. Furthermore, CNNs may incorrectly concentrate on other areas surrounding the salient object, rather than the network's attention focusing directly on the object to be recognized, as the network has no incentive to focus solely on the correct subjects to be detected. This inhibits the reliability of CNNs, especially for biomedical applications.

Authors

  • Kevin Chew Figueroa
    The University of Arizona, Wyant College of Optical Sciences, Tucson, Arizona, United States.
  • Bofan Song
    The University of Arizona, Wyant College of Optical Sciences, Tucson, Arizona, United States.
  • Sumsum Sunny
    Mazumdar Shaw Medical Centre, Bangalore, India.
  • Shaobai Li
    The University of Arizona, Wyant College of Optical Sciences, Tucson, Arizona, United States.
  • Keerthi Gurushanth
    KLE Society Institute of Dental Sciences, Bangalore, India.
  • Pramila Mendonca
    Mazumdar Shaw Medical Foundation, Bangalore, India.
  • Nirza Mukhia
    KLE Society Institute of Dental Sciences, Bangalore, India.
  • Sanjana Patrick
    Biocon Foundation, Bangalore, India.
  • Shubha Gurudath
    KLE Society Institute of Dental Sciences, Bangalore, India.
  • Subhashini Raghavan
    KLE Society Institute of Dental Sciences, Bangalore, India.
  • Tsusennaro Imchen
    Christian Institute of Health Sciences and Research, Dimapur, Nagaland, India.
  • Shirley T Leivon
    Christian Institute of Health Sciences and Research, Dimapur, India.
  • Trupti Kolur
    Mazumdar Shaw Medical Foundation, Bangalore, India.
  • Vivek Shetty
    Department of Head and Neck Surgical Oncology, Narayana Hrudhayalaya Hospitals, Bangalore, Karnataka, India.
  • Vidya Bushan
    Mazumdar Shaw Medical Foundation, Bangalore, India.
  • Rohan Ramesh
    Christian Institute of Health Sciences and Research, Dimapur, India.
  • Vijay Pillai
    Department of Head and Neck Surgical Oncology, Narayana Hrudhayalaya Hospitals, Bangalore, Karnataka, India.
  • Petra Wilder-Smith
    University of California Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
  • Alben Sigamani
    Mazumdar Shaw Medical Foundation, Bangalore, India.
  • Amritha Suresh
    Integrated Head and Neck Oncology Program, Mazumdar Shaw Centre for Translational Research, Bangalore, 560 099, India.
  • Moni Abraham Kuriakose
    Cochin Cancer Research Center, Kochi, India.
  • Praveen Birur
    KLE Society Institute of Dental Sciences, Bangalore, India.
  • Rongguang Liang