COVID-19 mortality prediction in the intensive care unit with deep learning based on longitudinal chest X-rays and clinical data.

Journal: European radiology
Published Date: Feb 19, 2022

Abstract

OBJECTIVES: We aimed to develop deep learning models using longitudinal chest X-rays (CXRs) and clinical data to predict in-hospital mortality of COVID-19 patients in the intensive care unit (ICU).

Authors

  • Jianhong Cheng
    Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, 932 Lushan S Rd, Yuelu District, Changsha, Hunan, China.
  • John Sollee
    Department of Diagnostic Radiology, Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA; Warren Alpert Medical School of Brown University, 222 Richmond St., Providence, RI 02903, USA.
  • Celina Hsieh
    Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA.
  • Hailin Yue
    Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, 932 Lushan S Rd, Yuelu District, Changsha, Hunan, China.
  • Nicholas Vandal
    Department of Diagnostic Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Justin Shanahan
    Department of Diagnostic Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Ji Whae Choi
    From the Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China (H.X.B., Z.X., D.C.W., W.H.L.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (H.X.B., B.H., K.H., I.P., M.K.A.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (R.W.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology. Massachusetts General Hospital, Boston, Mass (K.C.); Warren Alpert Medical School at Brown University, Providence, RI (H.X.B., K.H., T.M.L.T., J.W.C., I.P.); Department of Radiology, Yongzhou Central Hospital, Yongzhou, China (L.B.S.); Department of Radiology, Changde Second People's Hospital, Changde, China (J.M.); Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China (X.L.J.); Department of Radiology, Loudi Central Hospital, Loudi, China (Q.H.Z.); Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, China (P.F.H.); Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, China (Y.H.L.); Department of Radiology, Yiyang City Center Hospital, Yiyang, China (F.X.F.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (R.Y.H.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (R.S.); and Department of Radiology, The First Hospital of Changsha, Changsha, China (Q.Z.Y.).
  • Thi My Linh Tran
    From the Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China (H.X.B., Z.X., D.C.W., W.H.L.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (H.X.B., B.H., K.H., I.P., M.K.A.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (R.W.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology. Massachusetts General Hospital, Boston, Mass (K.C.); Warren Alpert Medical School at Brown University, Providence, RI (H.X.B., K.H., T.M.L.T., J.W.C., I.P.); Department of Radiology, Yongzhou Central Hospital, Yongzhou, China (L.B.S.); Department of Radiology, Changde Second People's Hospital, Changde, China (J.M.); Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China (X.L.J.); Department of Radiology, Loudi Central Hospital, Loudi, China (Q.H.Z.); Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, China (P.F.H.); Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, China (Y.H.L.); Department of Radiology, Yiyang City Center Hospital, Yiyang, China (F.X.F.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (R.Y.H.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (R.S.); and Department of Radiology, The First Hospital of Changsha, Changsha, China (Q.Z.Y.).
  • Kasey Halsey
    From the Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China (H.X.B., Z.X., D.C.W., W.H.L.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (H.X.B., B.H., K.H., I.P., M.K.A.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (R.W.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology. Massachusetts General Hospital, Boston, Mass (K.C.); Warren Alpert Medical School at Brown University, Providence, RI (H.X.B., K.H., T.M.L.T., J.W.C., I.P.); Department of Radiology, Yongzhou Central Hospital, Yongzhou, China (L.B.S.); Department of Radiology, Changde Second People's Hospital, Changde, China (J.M.); Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China (X.L.J.); Department of Radiology, Loudi Central Hospital, Loudi, China (Q.H.Z.); Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, China (P.F.H.); Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, China (Y.H.L.); Department of Radiology, Yiyang City Center Hospital, Yiyang, China (F.X.F.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (R.Y.H.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (R.S.); and Department of Radiology, The First Hospital of Changsha, Changsha, China (Q.Z.Y.).
  • Franklin Iheanacho
    Department of Diagnostic Radiology, Rhode Island Hospital, 593 Eddy St., Providence, RI, 02903, USA.
  • James Warren
    Department of Data Science, University of London, London, UK.
  • Abdullah Ahmed
    Department of Diagnostic Radiology, Rhode Island Hospital, 593 Eddy St., Providence, RI, 02903, USA.
  • Carsten Eickhoff
    Department of Computer Science, ETH Zurich, Zurich, Switzerland; Center for Biomedical Informatics, Brown University, Providence, RI, USA.
  • Michael Feldman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine Philadelphia, PA, United States; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
  • Eduardo Mortani Barbosa
    Department of Diagnostic Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Ihab Kamel
    Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland.
  • Cheng Ting Lin
    The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. clin97@jhmi.edu.
  • Thomas Yi
    Warren Alpert Medical School at Brown University, Providence, RI, USA.
  • Terrance Healey
    Department of Diagnostic Radiology, Rhode Island Hospital, 593 Eddy St., Providence, RI, 02903, USA.
  • Paul Zhang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia.
  • Jing Wu
    School of Pharmaceutical Science, Jiangnan University, Wuxi, 214122, Jiangsu, China.
  • Michael Atalay
    Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA.
  • Harrison X Bai
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Zhicheng Jiao
  • Jianxin Wang

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