[rhPDGF-BB promotes migration of bone marrow stromal stem cells in diabetic rats].

Journal: Shanghai kou qiang yi xue = Shanghai journal of stomatology
PMID: 30899936

Abstract

PURPOSE: To evaluate the effect of different concentrations of rhPDGF-BB on bone marrow stromal stem cells(BMSCs) migration in diabetic rat, and related mechanisms of SDF-1 and its G-protein conjugated receptor regulation, provide a theoretical basis for the application of rhPDGF-BB to diabetic patients for bone regeneration therapy.

Authors

  • De-Fang Wang
    Department of Prosthodontics, Shanghai Stomatological Hospital, Fudan University; Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University. Shanghai 200001, China. E-mail:wangdefang6243@126.com.
  • Yan Liu
    Department of Clinical Microbiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
  • Jue Wang
    State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR, China.

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