Deep learning methods for automatic evaluation of delayed enhancement-MRI. The results of the EMIDEC challenge.

Journal: Medical image analysis
Published Date:

Abstract

A key factor for assessing the state of the heart after myocardial infarction (MI) is to measure whether the myocardium segment is viable after reperfusion or revascularization therapy. Delayed enhancement-MRI or DE-MRI, which is performed 10 min after injection of the contrast agent, provides high contrast between viable and nonviable myocardium and is therefore a method of choice to evaluate the extent of MI. To automatically assess myocardial status, the results of the EMIDEC challenge that focused on this task are presented in this paper. The challenge's main objectives were twofold. First, to evaluate if deep learning methods can distinguish between non-infarct and pathological exams, i.e. exams with or without hyperenhanced area. Second, to automatically calculate the extent of myocardial infarction. The publicly available database consists of 150 exams divided into 50 cases without any hyperenhanced area after injection of a contrast agent and 100 cases with myocardial infarction (and then with a hyperenhanced area on DE-MRI), whatever their inclusion in the cardiac emergency department. Along with MRI, clinical characteristics are also provided. The obtained results issued from several works show that the automatic classification of an exam is a reachable task (the best method providing an accuracy of 0.92), and the automatic segmentation of the myocardium is possible. However, the segmentation of the diseased area needs to be improved, mainly due to the small size of these areas and the lack of contrast with the surrounding structures.

Authors

  • Alain Lalande
  • Zhihao Chen
    Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
  • Thibaut Pommier
    Department of Cardiology, University Hospital of Dijon, Dijon, France.
  • Thomas Decourselle
    CASIS Company, Quetigny, France.
  • Abdul Qayyum
    Department of Agronomy, The University of Haripur, Haripur 22620, Pakistan.
  • Michel Salomon
    FEMTO-ST Institute, UMR6174 CNRS, Univ. Bourgogne Franche-Comté, Belfort, France.
  • Dominique Ginhac
    ImViA Laboratory, University of Burgundy, Dijon, France.
  • Youssef Skandarani
    Philips Research France, 92150 Suresnes, France.
  • Arnaud Boucher
    ImViA Laboratory, University of Burgundy, Dijon, France.
  • Khawla Brahim
    ImViA Laboratory, University of Burgundy, Dijon, France; National Engineering School of Sousse, University of Sousse, Sousse, Tunisia; LASEE laboratory, National Engineering School of Monastir, University of Monastir, Monastir, Tunisia.
  • Marleen de Bruijne
  • Robin Camarasa
    Biomedical Imaging Group Rotterdam, Erasmus MC, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
  • Teresa M Correia
    Centre of Marine Sciences, University of Algarve, Faro, Portugal; School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
  • Xue Feng
    Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia.
  • Kibrom B Girum
    ImViA Laboratory, University of Burgundy, Dijon, France.
  • Anja Hennemuth
    Charité - Universitätsmedizin Berlin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany; German Centre for Cardiovascular Research, Berlin, Germany.
  • Markus Huellebrand
    Charité - Universitätsmedizin Berlin, Berlin, Germany; Fraunhofer MEVIS, Bremen, Germany.
  • Raabid Hussain
    ImViA Laboratory, University of Burgundy, Batiment I3M, 64b rue sully, 21000, Dijon, France.
  • Matthias Ivantsits
    Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Jun Ma
    State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
  • Craig Meyer
    Department of Biomedical Engineering, University of Virginia, Charlottesville, USA.
  • Rishabh Sharma
    Mechanical Engineering Department, The NorthCap University, Gurugram, Haryana, India.
  • Jixi Shi
    FEMTO-ST Institute, UMR6174 CNRS, Univ. Bourgogne Franche-Comté, Belfort, France; IRSEEM, EA4353, ESIGELEC, Univ. Normandie, Rouen, France.
  • Nikolaos V Tsekos
    Department of Computer Science, University of Houston, Houston, TX, USA. nvtsekos@central.uh.edu.
  • Marta Varela
    National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Xiyue Wang
    College of Electrical Engineering and Information Technology, Sichuan University, 610065, China. Electronic address: xiyue.wang.scu@gmail.com.
  • Sen Yang
    Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, 130012, China.
  • Hannu Zhang
    Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Yichi Zhang
    Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Yuncheng Zhou
    School of Data Science, Fudan University, Shanghai, China.
  • Xiahai Zhuang
    School of Data Science, Fudan University, Shanghai, China; Fudan-Xinzailing Joint Research Center for Big Data, Fudan University, Shanghai, China. Electronic address: zxh@fudan.edu.cn.
  • Raphaël Couturier
    FEMTO-ST Institute, UMR6174 CNRS, Univ. Bourgogne Franche-Comté, Belfort, France. Electronic address: raphael.couturier@univ-fcomte.fr.
  • Fabrice Meriaudeau
    LE2I, CNRS, Arts et Métiers, Université Bourgogne Franche-Comté, 12 rue de la Fonderie, Le Creusot, France. fabrice.meriaudeau@utp.edu.my.