AIMC Topic: Myocardium

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Multimodal Optical Imaging Combined with Radiomic Analysis for Fibrotic Cardiac Tissue Investigation.

Analytical chemistry Jul 5, 2025
Understanding the process of fibrotic scarring of the myocardium is critical for the diagnosis and risk stratification of life-threatening cardiac dysfunction. Complex changes in structure, composition, and conductivity occurring at different stages ...
Radiomics Animals Rats Spectrum Analysis, Raman Myocardium Multimodal Imaging Fibrosis Optical Imaging Tomography, Optical Coherence Microscopy, Fluorescence, Multiphoton
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Investigating methods to enhance interpretability and performance in cardiac MRI for myocardial scarring diagnosis using convolutional neural network classification and One Match.

PloS one Jun 9, 2025
Machine learning (ML) classification of myocardial scarring in cardiac MRI is often hindered by limited explainability, particularly with convolutional neural networks (CNNs). To address this, we developed One Match (OM), an algorithm that builds on ...
Myocardium Heart Image Interpretation, Computer-Assisted Convolutional Neural Networks Magnetic Resonance Imaging Cicatrix Neural Networks, Computer Machine Learning Algorithms Male Middle Aged Female Aged Humans
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A high-throughput analysis of novel anti-fibrotics in human adult cardiac fibroblasts.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Jun 3, 2025
Myocardial fibrosis, a hallmark of heart failure (HF), contributes to disease progression and mortality by impairing cardiac function. Despite the identification of potential anti-fibrotic molecules, there is a lack of effective pharmacological inter...
High-Throughput Screening Assays Cells, Cultured Fibroblasts Humans Antifibrotic Agents Myocardium Fibrosis
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One-Drop Serum Screening Test to Monitor Tissue Iron Accumulation.

Analytical chemistry May 30, 2025
Although iron is an essential element for vital body functions, iron overload (IO) is accompanied by significant cellular damage due to its accumulation within organs. Thus, early diagnosis and accurate identification of the affected organs are criti...
Humans Spectroscopy, Fourier Transform Infrared Liver Myocardium Iron Animals Male Kidney Iron Overload Spleen
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Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling.

Drug design, development and therapy Apr 21, 2025
PURPOSE: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.
Cell Line Animals Mice Muscle, Skeletal Myocardium Galactose Drugs, Chinese Herbal Male Mitochondria Rats Aging Mice, Inbred C57BL
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U-shaped network combining dual-stream fusion mamba and redesigned multilayer perceptron for myocardial pathology segmentation.

Medical physics Apr 17, 2025
BACKGROUND: Cardiac magnetic resonance imaging (CMR) provides critical pathological information, such as scars and edema, which are vital for diagnosing myocardial infarction (MI). However, due to the limited pathological information in single-sequen...
Myocardium Heart Myocardial Infarction Multilayer Perceptrons Neural Networks, Computer Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging
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Proteomics and Machine Learning-Based Approach to Decipher Subcellular Proteome of Mouse Heart.

Molecular & cellular proteomics : MCP Mar 18, 2025
Protein compartmentalization to distinctive subcellular niches is critical for cardiac function and homeostasis. Here, we employed a rapid and robust workflow based on differential centrifugal-based fractionation with mass spectrometry-based proteomi...
Male Myocardium Subcellular Fractions Mice Proteomics Machine Learning Proteome Animals Mice, Inbred C57BL
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Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing.

Small (Weinheim an der Bergstrasse, Germany) Feb 5, 2025
Democratizing biomarker testing at the point-of-care requires innovations that match laboratory-grade sensitivity and precision in an accessible format. Here, high-sensitivity detection of cardiac troponin I (cTnI) is demonstrated through innovations...
Luminescent Measurements Myocardial Infarction Troponin I Biomarkers Deep Learning Limit of Detection Humans Myocardium
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Machine learning-based interpretation of non-contrast feature tracking strain analysis and T1/T2 mapping for assessing myocardial viability.

Scientific reports Jan 4, 2025
Assessing myocardial viability is crucial for managing ischemic heart disease. While late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is the gold standard for viability evaluation, it has limitations, including contraindicati...
Female Aged Male Myocardial Infarction Humans Middle Aged Magnetic Resonance Imaging Image Interpretation, Computer-Assisted Machine Learning Contrast Media Myocardium Retrospective Studies
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Leveraging a Vision Transformer Model to Improve Diagnostic Accuracy of Cardiac Amyloidosis With Cardiac Magnetic Resonance.

JACC. Cardiovascular imaging Dec 4, 2024
BACKGROUND: Cardiac magnetic resonance (CMR) imaging is an important diagnostic tool for diagnosis of cardiac amyloidosis (CA). However, discrimination of CA from other etiologies of myocardial disease can be challenging.
Reproducibility of Results Aged Amyloidosis Male Cardiomyopathies Middle Aged Humans Predictive Value of Tests Magnetic Resonance Imaging, Cine Decision Support Techniques Deep Learning Myocardium Image Interpretation, Computer-Assisted Retrospective Studies Contrast Media Female Cardiomyopathy, Hypertrophic Diagnosis, Differential
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