Detection of potential new biomarkers of atherosclerosis by probe electrospray ionization mass spectrometry.

Journal: Metabolomics : Official journal of the Metabolomic Society
Published Date: Feb 27, 2018

Abstract

INTRODUCTION: Atherosclerotic diseases are the leading cause of death worldwide. Biomarkers of atherosclerosis are required to monitor and prevent disease progression. While mass spectrometry is a promising technique to search for such biomarkers, its clinical application is hampered by the laborious processes for sample preparation and analysis.

Authors

  • Hisashi Johno
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
  • Kentaro Yoshimura
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan. kyoshimura@yamanashi.ac.jp.
  • Yuki Mori
    Graduate School of Human-Environment Studies, Kyushu University, Fukuoka, Japan.
  • Tokuhide Kimura
    Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
  • Manabu Niimi
    Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
  • Masaki Yamada
    Analytical and Measuring Instruments Division, Global Application Development Center, Shimadzu Corporation, Kyoto, 604-8511, Japan.
  • Tetsuo Tanigawa
    Analytical and Measuring Instruments Division, Global Application Development Center, Shimadzu Corporation, Kyoto, 604-8511, Japan.
  • Jianglin Fan
    Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
  • Sen Takeda
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan. stakeda@yamanashi.ac.jp.

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