Deep learning-enabled pelvic ultrasound images for accurate diagnosis of ovarian cancer in China: a retrospective, multicentre, diagnostic study.

Journal: The Lancet. Digital health
Published Date:

Abstract

BACKGROUND: Ultrasound is a critical non-invasive test for preoperative diagnosis of ovarian cancer. Deep learning is making advances in image-recognition tasks; therefore, we aimed to develop a deep convolutional neural network (DCNN) model that automates evaluation of ultrasound images and to facilitate a more accurate diagnosis of ovarian cancer than existing methods.

Authors

  • Yue Gao
    Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
  • Shaoqing Zeng
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Xiaoyan Xu
    School of Control Science and Engineering, Shandong University, Jinan 250061, China.
  • Huayi Li
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Shuzhong Yao
    Department of Obstetrics and Gynecology, Precision Medicine Institute, Sun Yat-sen University, Yuexiu, Guangzhou, Guangdong, China.
  • Kun Song
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, 250012, China.
  • Xiao Li
    Department of Inner Mongolia Clinical Medicine College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
  • Lingxi Chen
    Department of Computer Science, City University of Hong Kong, Hong Kong 99907, China.
  • Junying Tang
    First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Hui Xing
    Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, China.
  • Zhiying Yu
    Department of Gynecology, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center.
  • Qinghua Zhang
    Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Shue Zeng
    Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cunjian Yi
    Department of Obstetrics and Gynecology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
  • Hongning Xie
    Department of Ultrasonic Medicine, Fetal Medical Center, First Affiliated Hospital of Sun Yat-sen University, Zhongshan Er Road 58, Guangzhou, 510080, Guangdong, China. hongning_x@126.com.
  • Xiaoming Xiong
    Cancer Biology Research Center, Key Laboratory of Chinese Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
  • Guangyao Cai
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Zhi Wang
    Department of Pharmacy, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Yuan Wu
    State Key Laboratory of Precision Spectroscopy, Quantum Institute for Light and Atoms, Department of Physics and Electronic Science, East China Normal University, Shanghai 200062, China.
  • Jianhua Chi
    Cancer Biology Research Center, Key Laboratory of Chinese Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
  • Xiaofei Jiao
    Cancer Biology Research Center, Key Laboratory of Chinese Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
  • Yan Qin
    First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Xiaogang Mao
    Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Yu Chen
    State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
  • Xin Jin
    Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China.
  • Qingqing Mo
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Pingbo Chen
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Yi Huang
    Department of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, China.
  • Yushuang Shi
    Department of Obstetrics and Gynecology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
  • Junmei Wang
    Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, University of Pittsburgh, 3501 Terrace St, Pittsburgh, PA, 15213, USA; Department of Pharmaceutical Sciences, School of Pharmacy, NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, 3501 Terrace St, Pittsburgh, PA, 15213, USA. Electronic address: junmei.wang@pitt.edu.
  • Yimin Zhou
    Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Shuping Ding
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Shan Zhu
    Tianjin Hospital, Tianjin 300211, P.R. China.
  • Xin Liu
    Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences, Weifang, Shandong, China.
  • Xiangyi Dong
    Gynecology Oncology Key Laboratory, Qilu Hospital, Shandong University, Jinan City, China.
  • Lin Cheng
    Department of Radiology, Southwest Hospital, Third Military Medical University (Army Military Medical University), Chongqing, China.
  • Linlin Zhu
    Digestive Endoscopic Center of West China Hospital, Sichuan University, Chengdu, 610017, China.
  • Huanhuan Cheng
  • Li Cha
    Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yanli Hao
    Department of Gynecology, The Second People's Hospital of Shenzhen, Shenzhen, China.
  • Chunchun Jin
    Department of Gynecology, The Second People's Hospital of Shenzhen, Shenzhen, China.
  • Ludan Zhang
    Center of Digital Dentistry, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Research Center of Engineering and Technology for Digital Dentistry of Ministry of Health & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
  • Peng Zhou
    School of International Studies, Zhejiang University, Hangzhou, China.
  • Meng Sun
    Department of Gynecology, The Second People's Hospital of Shenzhen, Shenzhen, China.
  • Qin Xu
  • Kehua Chen
    Department of Gynecology, The Second People's Hospital of Shenzhen, Shenzhen, China.
  • Zeyan Gao
    Department of Gynecology, The Second People's Hospital of Shenzhen, Shenzhen, China.
  • Xu Zhang
    China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Yuanyuan Ma
    Department of Gynecology, The Second People's Hospital of Shenzhen, Shenzhen, China.
  • Yan Liu
    Department of Clinical Microbiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
  • Liling Xiao
    Department of Gynecology, The Second People's Hospital of Shenzhen, Shenzhen, China.
  • Li Xu
    College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Lin Peng
    Department of dermatology, Tongji University Affiliated Tongji Hospital, Shanghai, China.
  • Zheyu Hao
    Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Mi Yang
    Department of Neurology, School of Medicine, The Fourth Affiliated Hospital of Zhejiang University, Yiwu, China.
  • Yane Wang
    Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Hongping Ou
    Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Yongmei Jia
    Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Lihua Tian
    Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Ping Jin
    Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xun Tian
    Department of Obstetrics and Gynecology, Academician Expert Workstation, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Lei Huang
    School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.
  • Zhen Wang
    Department of Otolaryngology, Longgang Otolaryngology hospital & Shenzhen Key Laboratory of Otolaryngology, Shenzhen Institute of Otolaryngology, Shenzhen, Guangdong, China.
  • Jiahao Liu
    School of Artificial Intelligence, Hebei University of Technology, Tianjin, 300130, China.
  • Tian Fang
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Danmei Yan
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Heng Cao
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Jingjing Ma
    Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Xiaoting Li
    Department of Medicine, Leshan Vocational and Technical College, No. 1336, Middle Section of Qingyijiang Avenue, Shizhong District, Leshan City, Sichuan Province, China.
  • Xu Zheng
    Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Hua Lou
    Changzhou College of Information Technology, ChangZhou, China.
  • Chunyan Song
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Ruyuan Li
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Siyuan Wang
    Key Laboratory of Agricultural Information Acquisition Technology, Ministry of Agriculture and Key Laboratory of Modern Precision Agriculture System Integration Research, Ministry of Education, China Agricultural University, Beijing, 100083, People's Republic of China.
  • Wenqian Li
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Xulei Zheng
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Jing Chen
    Department of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
  • Guannan Li
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Ruqi Chen
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Cheng Xu
    School of Photovoltaic and Renewable Energy Engineering, University of New South Wales, 2052 Sydney, Australia.
  • Ruidi Yu
    National Clinical Research Center for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education) and Department of Gynaecology and Obstetrics, Tongji Hospital, Wuhan, China.
  • Ji Wang
    Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China.
  • Sen Xu
    National Medical Center for Major Public Health Events, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
  • Beihua Kong
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, 250012, China.
  • Xing Xie
    Microsoft Research, China. Electronic address: xing.xie@microsoft.com.
  • Ding Ma
    Department of Obstetrics and Gynaecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Qinglei Gao
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.