Initial results of pulmonary resection after neoadjuvant nivolumab in patients with resectable non-small cell lung cancer.

Journal: The Journal of thoracic and cardiovascular surgery
PMID:

Abstract

OBJECTIVE: We conducted a phase I trial of neoadjuvant nivolumab, a monoclonal antibody to the programmed cell death protein 1 checkpoint receptor, in patients with resectable non-small cell lung cancer. We analyzed perioperative outcomes to assess the safety of this strategy.

Authors

  • Matthew J Bott
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Stephen C Yang
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Md.
  • Bernard J Park
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Prasad S Adusumilli
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Valerie W Rusch
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • James M Isbell
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Robert J Downey
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Julie R Brahmer
    Sidney Kimmel Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Md.
  • Richard Battafarano
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Md.
  • Errol Bush
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Md.
  • Jamie Chaft
    Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, and Weill Cornell Medical College, New York, NY.
  • Patrick M Forde
    Sidney Kimmel Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Md.
  • David R Jones
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Stephen R Broderick
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Md. Electronic address: sbroder7@jhmi.edu.