Safety and feasibility study of non-invasive robot-assisted high-intensity focused ultrasound therapy for the treatment of atherosclerotic plaques in the femoral artery: protocol for a pilot study.

Journal: BMJ open
PMID: 35501090

Abstract

INTRODUCTION: Peripheral arterial disease (PAD) is an atherosclerotic disease leading to stenosis and/or occlusion of the arterial circulation of the lower extremities. The currently available revascularisation methods have an acceptable initial success rate, but the long-term patency is limited, while surgical revascularisation is associated with a relatively high perioperative risk. This urges the need for development of less invasive and more effective treatment modalities. This protocol article describes a study investigating a new non-invasive technique that uses robot assisted high-intensity focused ultrasound (HIFU) to treat atherosclerosis in the femoral artery.

Authors

  • Michelle V Simons
    Department of Vascular Medicine, University Medical Centre, Utrecht, The Netherlands michelle.valerie.simons@hotmail.com.
  • Marijn H A Groen
    Department of Cardiology, University Medical Centre, Utrecht, The Netherlands.
  • Gert J de Borst
    Vascular Surgery, University Medical Centre Speciality Surgery, Utrecht, The Netherlands.
  • Tim Leiner
    Departments of Radiology and Nuclear Medicine (C.P.S.B., A.J.N., P.v.O., R.N.P.) and Cardiology (S.M.B.), Amsterdam University Medical Centers, Location Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.M.W.); Department of Research and Development, Pie Medical Imaging BV, Maastricht, the Netherlands (J.P.A.); and Departments of Cardiology (G.P.B., S.A.J.C.) and Radiology (T.L.), University Medical Center Utrecht, Utrecht, the Netherlands.
  • Pieter A F Doevendans
    Department of Cardiology, University Medical Centre, Utrecht, The Netherlands.
  • Emad Ebbini
    Electrical and Computer Engineering, University of Minnesota College of Science and Engineering, Minneapolis, Minnesota, USA.
  • Fons J B Slieker
    Department of Oral Surgery, University Medical Centre, Utrecht, The Netherlands.
  • RenĂ© van Es
    Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
  • Constantijn E V B Hazenberg
    Vascular Surgery, University Medical Centre Speciality Surgery, Utrecht, The Netherlands.

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