Development of a deep learning model for the histologic diagnosis of dysplasia in Barrett's esophagus.

Journal: Gastrointestinal endoscopy
PMID: 35718071

Abstract

BACKGROUND AND AIMS: The risk of progression in Barrett's esophagus (BE) increases with development of dysplasia. There is a critical need to improve the diagnosis of BE dysplasia, given substantial interobserver disagreement among expert pathologists and overdiagnosis of dysplasia by community pathologists. We developed a deep learning model to predict dysplasia grade on whole-slide imaging.

Authors

  • Shahriar Faghani
    Mayo Clinic Artificial Intelligence Lab, Department of Radiology, Mayo Clinic, 200 1st Street, S.W., Rochester, MN, 55905, USA.
  • D Chamil Codipilly
    Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
  • David Vogelsang
    Artificial Intelligence Laboratory, Mayo Clinic, Rochester, Minnesota, USA; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Mana Moassefi
    Mayo Clinic Artificial Intelligence Lab, Department of Radiology, Mayo Clinic, 200 1st Street, S.W., Rochester, MN, 55905, USA.
  • Pouria Rouzrokh
    Department of Radiology, Mayo Clinic, Radiology Informatics Laboratory, Rochester, MN.
  • Bardia Khosravi
    Department of Radiology, Radiology Informatics Lab, Mayo Clinic, Rochester, MN 55905, United States.
  • Siddharth Agarwal
    School of Biomedical Engineering and Imaging Sciences, King's College London, United Kingdom.
  • Lovekirat Dhaliwal
    Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
  • David A Katzka
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States.
  • Catherine Hagen
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA; (5)Department of Pathology, Mayo Clinic, Jacksonville, Florida, USA.
  • Jason Lewis
    Department of Pathology, Mayo Clinic, Jacksonville, Florida, USA.
  • Cadman L Leggett
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
  • Bradley J Erickson
    Department of Radiology, Radiology Informatics Lab, Mayo Clinic, Rochester, MN 55905, United States.
  • Prasad G Iyer
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

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