AIMC Topic: Esophageal Neoplasms

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Quantitative image analysis of the extracellular matrix of esophageal squamous cell carcinoma and high grade dysplasia via two-photon microscopy.

Scientific reports
Squamous cell carcinoma (SCC) and high-grade dysplasia (HGD) are two different pathological entities; however, they sometimes share similarities in histological structure depending on the context. Thus, distinguishing between the two may require care...

Development and validation of a nomogram model to predict postoperative delirium after resection of esophageal cancer.

Scientific reports
The study aimed to establish and validate a nomogram model to predict postoperative delirium (POD) among esophageal cancer resection patients. Clinical data of 396 patients with esophageal cancer who underwent esophagectomy from November 2020 to June...

Developing a machine-learning model to enable treatment selection for neoadjuvant chemotherapy for esophageal cancer.

Scientific reports
Although neoadjuvant chemotherapy with docetaxel + cisplatin + 5-fluorouracil (CF) has been the standard treatment for stage II and III esophageal cancers, it is associated with severe adverse events caused by docetaxel. Consequently, this study aime...

A ubiquitous and interoperable deep learning model for automatic detection of pleomorphic gastroesophageal lesions.

Scientific reports
In recent years, artificial intelligence (AI) has been widely explored to enhance capsule endoscopy (CE), with the goal of improving the efficiency of the reading process. While most AI models have been developed for small bowel and colon analysis, t...

Development and validation of CT-based fusion model for preoperative prediction of invasion and lymph node metastasis in adenocarcinoma of esophagogastric junction.

BMC medical imaging
PURPOSE: In the context of precision medicine, radiomics has become a key technology in solving medical problems. For adenocarcinoma of esophagogastric junction (AEG), developing a preoperative CT-based prediction model for AEG invasion and lymph nod...

Biomarker risk stratification with capsule sponge in the surveillance of Barrett's oesophagus: prospective evaluation of UK real-world implementation.

Lancet (London, England)
BACKGROUND: Endoscopic surveillance is the clinical standard for Barrett's oesophagus, but its effectiveness is inconsistent. We have developed a test comprising a pan-oesophageal cell collection device coupled with biomarkers to stratify patients in...

Deep learning dosiomics in grade 4 radiation-induced lymphopenia prediction in radiotherapy for esophageal cancer: a multi-center study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
PURPOSE: To investigate the feasibility and accuracy of using deep learning and dosiomics features, as well as their combination with dose-volume histogram (DVH) parameters and clinical factors to predict grade 4 radiation-induced lymphopenia (G4RIL)...

Cone-beam computed tomography-based online adaptive radiotherapy of esophageal cancer in the neoadjuvant setting: Dosimetric analysis, toxicity and treatment response.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
BACKGROUND AND PURPOSE: Chemoradiotherapy (CRT) followed by surgery is a treatment option for esophageal cancer (EC). However, concerns persist regarding cardiopulmonary toxicity and inconsistent daily target coverage due to anatomical changes. To ad...

Immunohistochemical biomarker scoring in gastroesophageal cancers: Can computers help us?

Pathology, research and practice
The increasing complexity of cancer diagnostics and treatment selection has placed a growing burden on pathologists, particularly in the evaluation of immunohistochemical (IHC) biomarkers. In gastroesophageal cancers (GEC), both adenocarcinoma and sq...

An integrated analytical approach for biomarker discovery in esophageal cancer: Combining trace element and oxidative stress profiling with machine learning.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
BACKGROUND: Early detection of esophageal squamous cell carcinoma (ESCC) significantly improves survival rates, yet reliable biochemical biomarkers for early diagnosis remain limited. The aim of this study is to identify potential early diagnostic bi...