Optimizing Outcome Prediction in Diffuse Large B-Cell Lymphoma by Use of Machine Learning and Nationwide Lymphoma Registries: A Nordic Lymphoma Group Study.

Journal: JCO clinical cancer informatics
PMID: 30652603

Abstract

PURPOSE: Prognostic models for diffuse large B-cell lymphoma (DLBCL), such as the International Prognostic Index (IPI) are widely used in clinical practice. The models are typically developed with simplicity in mind and thus do not exploit the full potential of detailed clinical data. This study investigated whether nationwide lymphoma registries containing clinical data and machine learning techniques could prove to be useful for building modern prognostic tools.

Authors

  • Jorne L Biccler
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Sandra Eloranta
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Peter de Nully Brown
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Henrik Frederiksen
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Mats Jerkeman
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Judit Jørgensen
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Lasse Hjort Jakobsen
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Karin E Smedby
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Martin Bøgsted
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.
  • Tarec C El-Galaly
    Jorne L. Biccler, Lasse Hjort Jakobsen, Martin Bøgsted, and Tarec C. El-Galaly, Aalborg University Hospital and Aalborg University, Aalborg; Peter de Nully Brown, Copenhagen University Hospital, Copenhagen; Henrik Frederiksen, Odense University Hospital, Odense; Judit Jørgensen, Aarhus University Hospital, Aarhus; Denmark; Sandra Eloranta and Karin E. Smedby, Karolinska Institutet, Stockholm; Mats Jerkeman, Lund University, Lund; and Karin E. Smedby, Karolinska University Hospital, Solna, Sweden.

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