Quantifying the post-radiation accelerated brain aging rate in glioma patients with deep learning.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Published Date: Aug 10, 2022

Abstract

BACKGROUND AND PURPOSE: Changes of healthy appearing brain tissue after radiotherapy (RT) have been previously observed. Patients undergoing RT may have a higher risk of cognitive decline, leading to a reduced quality of life. The experienced tissue atrophy is similar to the effects of normal aging in healthy individuals. We propose a new way to quantify tissue changes after cranial RT as accelerated brain aging using the BrainAGE framework.

Authors

  • Selena I Huisman
    Department of Radiation Oncology, UMC Utrecht, 3584 CX Utrecht, The Netherlands. Electronic address: Selena.Isabelle.Huisman@gmail.com.
  • Arthur T J van der Boog
    Department of Radiation Oncology, UMC Utrecht, 3584 CX Utrecht, The Netherlands. Electronic address: A.T.J.vanderBoog-4@umcutrecht.nl.
  • Fia Cialdella
    Department of Radiation Oncology, UMC Utrecht, 3584 CX Utrecht, The Netherlands; Department of Medical Oncology, UMC Utrecht, 3584 CX Utrecht, The Netherlands. Electronic address: F.Cialdella@umcutrecht.nl.
  • Joost J C Verhoeff
    Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Szabolcs David
    Department of Radiation Oncology, UMC Utrecht, 3584 CX Utrecht, The Netherlands. Electronic address: s.david@umcutrecht.nl.

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