Deep-learning-based hepatic fat assessment (DeHFt) on non-contrast chest CT and its association with disease severity in COVID-19 infections: A multi-site retrospective study.

Journal: EBioMedicine
Published Date: Oct 26, 2022

Abstract

BACKGROUND: Hepatic steatosis (HS) identified on CT may provide an integrated cardiometabolic and COVID-19 risk assessment. This study presents a deep-learning-based hepatic fat assessment (DeHFt) pipeline for (a) more standardised measurements and (b) investigating the association between HS (liver-to-spleen attenuation ratio <1 in CT) and COVID-19 infections severity, wherein severity is defined as requiring invasive mechanical ventilation, extracorporeal membrane oxygenation, death.

Authors

  • Gourav Modanwal
    Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. Electronic address: gourav.modanwal@emory.edu.
  • Sadeer Al-Kindi
    Division of Cardiology, Department of Medicine (S.A.-K., F.N., G.F.A., M.A.C., D.I.S., M.S.A., J.A.M., S.G.T.), Case Western Reserve University, Harrington Heart and Vascular Institute, and University Hospitals Cleveland Medical Center, OH.
  • Jonathan Walker
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
  • Rohan Dhamdhere
    Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
  • Lei Yuan
    Department of Pharmacy, Baodi People's Hospital, Tianjin, China.
  • Mengyao Ji
    School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China.
  • Cheng Lu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China. lv_cheng0816@163.com.
  • Pingfu Fu
    Department of Biomedical Engineering, Case Western Reserve University School of Engineering, 2071 Martin Luther King Dr, Cleveland, OH 44106-7207 (M. Khorrami, K.B., A.M.); Departments of Internal Medicine (M. Khunger) and Solid Tumor Oncology (A.Z., P.P.), Cleveland Clinic, Cleveland, Ohio; Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio (P.F.); Department of Hematology and Oncology, New York University, New York, NY (V.V.); Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, Ohio (A.M.).
  • Sanjay Rajagopalan
    Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
  • Anant Madabhushi
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

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