AcSDKP is down-regulated in anaemia induced by infection in mice.

Journal: Malawi medical journal : the journal of Medical Association of Malawi
PMID: 29872517

Abstract

BACKGROUND: Anaemia commonly results from destruction of erythrocytes in the peripheral blood and failure of the bone marrow haematopoietic cells to replenish the erythrocytes. The mechanisms involved in trypanosoma-induced anaemia, including the role of the bone marrow haematopoietic cells are incompletely understood. We studied the responses of a tetrapeptide, AcSDKP, and IL-10, and their association with bone marrow nucleated cells in a GVR35 experimental infection model.

Authors

  • Janelisa Musaya
    Department of Pathology, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Enock Matovu
    Department of Veterinary Medicine, Makerere University, Kampala, Uganda.
  • Edward Senga
    Department of Biomedical Sciences, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Moffat Nyirenda
    Malawi Epidemiology and Intervention Research Unit (MEIRU), Lilongwe, Malawi.
  • John Chisi
    Department of Biomedical Sciences, College of Medicine, University of Malawi, Blantyre, Malawi.

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