AIMC Topic: Interleukin-10

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Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia.

Drug delivery Mar 3, 2025
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...
Mice RNA, Messenger Nanoparticles Lipopolysaccharides Machine Learning Interleukin-10 Drug Delivery Systems Animals Hyaluronic Acid Liposomes Transfection Green Fluorescent Proteins Cell Line Lipids Microglia Immunologic Factors
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StackIL10: A stacking ensemble model for the improved prediction of IL-10 inducing peptides.

PloS one Nov 14, 2024
Interleukin-10, a highly effective cytokine recognized for its anti-inflammatory properties, plays a critical role in the immune system. In addition to its well-documented capacity to mitigate inflammation, IL-10 can unexpectedly demonstrate pro-infl...
Humans Machine Learning Algorithms Interleukin-10 Peptides
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Prediction of six macrophage phenotypes and their IL-10 content based on single-cell morphology using artificial intelligence.

Frontiers in immunology Jan 4, 2024
INTRODUCTION: The last decade has led to rapid developments and increased usage of computational tools at the single-cell level. However, our knowledge remains limited in how extracellular cues alter quantitative macrophage morphology and how such mo...
Cells, Cultured Interleukin-10 Humans Macrophage Colony-Stimulating Factor Artificial Intelligence Macrophages Tumor Necrosis Factor-alpha Granulocyte-Macrophage Colony-Stimulating Factor Cytokines Interleukin-4 Phenotype
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Decreased gremlin 1 expression in women with BMI ≥35 kg/m is mediated by interleukin 10 and interleukin 1β in the follicular fluid.

F&S science Jun 29, 2020
OBJECTIVE: To determine how body mass index (BMI) affects the follicular fluid cytokine milieu and investigate how this inflammatory environment impacts cumulus signaling.
Humans Obesity Interleukin-10 Interleukin-1beta Female Follicular Fluid Body Mass Index Intercellular Signaling Peptides and Proteins
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The effects of a therapeutic formalin bath on selected immunological and oxidative stress parameters in common carp (Cyprinus carpio).

The Science of the total environment Nov 5, 2018
Formalin is commonly used as a component of antiparasitic baths in fisheries. In this study the impact of this bath on the immune profile and oxidative stress parameters was evaluated. A formalin bath was prepared in the concentration of 185.3 mg L (...
Interleukin-10 Animals Time Factors Carps Oxidative Stress Interleukin-1beta Formaldehyde Gills Transforming Growth Factor beta Antiparasitic Agents
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Catechin rich butanol fraction extracted from Acacia catechu L. (a thirst quencher) exhibits immunostimulatory potential.

Journal of food and drug analysis Jul 2, 2018
Acacia catechu L., (Fabaceae) named as "catechu" is a plant, the decoction of heartwood of which is daily consumed as thirst quencher by a good percentage of the population in South India. The plant is mainly distributed in India and other Asian coun...
Erythrocytes Acacia Phagocytosis Immunologic Factors Sheep Catechin Animals Mice Interleukin-10 Plant Extracts Macrophages Nitric Oxide
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Gradient Boosted Decision Tree Classification of Endophthalmitis Versus Uveitis and Lymphoma from Aqueous and Vitreous IL-6 and IL-10 Levels.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Feb 3, 2017
PURPOSE: To investigate the effectiveness of gradient boosting to classify endophthalmitis versus uveitis and lymphoma by intraocular cytokine levels.
Endophthalmitis Interleukin-10 Interleukin-6 Water ROC Curve Lymphoma Decision Trees Data Interpretation, Statistical Uveitis Humans Machine Learning
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Serum profile of cytokines interferon gamma and interleukin-10 in ewes subjected to artificial insemination by cervical retraction.

Theriogenology Dec 23, 2015
This study evaluated the influence of artificial insemination (AI) by cervical retraction (CRI) on serum levels of interferon gamma (IFNγ) and interleukin-10 (IL-10) in ewes. Synchronized pluriparous Santa Inês ewes were subjected to natural mating (...
Interleukin-10 Pregnancy Female Animals Progesterone Sheep Insemination, Artificial Interferon-gamma
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Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus.

Journal of diabetes research Dec 6, 2015
This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (album...
Fibrin Fibrinogen Degradation Products ADAMTS13 Protein Albuminuria ADAM Proteins von Willebrand Factor Interferon-gamma Humans Adolescent Tumor Necrosis Factor-alpha Young Adult Interleukin-10 Diabetic Nephropathies Adult Interleukin-6 Diabetes Mellitus, Type 1 Male Biomarkers Renal Insufficiency, Chronic Middle Aged Female
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Clinical and inflammatory features based machine learning model for fatal risk prediction of hospitalized COVID-19 patients: results from a retrospective cohort study.

Annals of medicine Dec 1, 2021
OBJECTIVES: To appraise effective predictors for COVID-19 mortality in a retrospective cohort study.
Interleukin-10 Prognosis Retrospective Studies Female Humans Machine Learning COVID-19 Aged, 80 and over Adult Male Cardiovascular Diseases Reproducibility of Results SARS-CoV-2 Hospitalization Aged Ferritins L-Lactate Dehydrogenase Clinical Decision Rules Cohort Studies Middle Aged Hypertension Comorbidity Diabetes Mellitus Severity of Illness Index C-Reactive Protein China
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