Journal of chemical information and modeling
Dec 13, 2025
Molecular dynamics (MD) simulations are powerful tools for studying biomolecular systems, but they are fundamentally limited by accessible time scales, making the study of rare events such as protein folding or ligand unbinding computationally challe...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Nov 3, 2025
Metastatic castration-resistant prostate cancer has a high rate of mortality with a limited number of effective treatments after hormone therapy. Radiopharmaceutical therapy with [Lu]Lu-prostate-specific membrane antigen-617 (LuPSMA) is one treatment...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Nov 3, 2025
Prostate-specific membrane antigen (PSMA) PET has the potential to monitor the response to taxane-based chemotherapy in patients with prostate cancer and shows promise for predicting outcomes and improving response evaluation. This retrospective stud...
The lengthy 1 h dynamic positron emission tomography (PET) scans discomfort patients, add motion artifacts, and inflate costs, highlighting the need for tech advancements to reduce scan times. Therefore, we attempted to reconstruct multi-parametric i...
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
May 1, 2025
This study investigated the added value of using maximum-intensity projection (MIP) images for fully automatic segmentation of lesions using deep learning (DL) in [F]FDG and [Ga]Ga-prostate-specific membrane antigen (PSMA) PET/CT scans. We used 489 ...
Previous research showed that a peptide composed of three tyrosines (YYY) can turn into organic glass and cause strong adhesion between substrates via evaporation. However, the mechanisms of these processes remain unclear, and the exploration of appl...
European journal of nuclear medicine and molecular imaging
Feb 19, 2025
PURPOSE: Accurate prediction of adverse pathology (AP) in prostate cancer (PCa) patients is crucial for formulating effective treatment strategies. This study aims to develop and evaluate a multimodal deep learning model based on [F]PSMA-1007 PET/CT ...
Journal of chemical theory and computation
Nov 26, 2024
The weighted ensemble (WE) method stands out as a widely used segment-based sampling technique renowned for its rigorous treatment of kinetics. The WE framework typically involves initially mapping the configuration space onto a low-dimensional colle...
PURPOSE: This study demonstrates the feasibility and benefits of using a deep learning-based approach for attenuation correction in [ 68 Ga]Ga-PSMA PET scans.
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