PTPRC promoted CD8+ T cell mediated tumor immunity and drug sensitivity in breast cancer: based on pan-cancer analysis and artificial intelligence modeling of immunogenic cell death-based drug sensitivity stratification.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: Immunogenic cell death (ICD) is a result of immune cell infiltration (ICI)-mediated cell death, which is also a novel acknowledgment to regulate cellular stressor-mediated cell death, including drug therapy and radiotherapy.

Authors

  • Pengping Li
    Department of Thyroid & Breast Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
  • Shaowen Wang
    Department of Geography and Geographic Information Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Guodong Cao
    The Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Tonghe Pan
    The Department of Ningbo Eye Hospital, Affiliated to Wenzhou Medical University, Ningbo, Zhejiang, China.
  • Yuqing Huang
    Department of Thoracic Surgery, Beijing Haidian Hospital, Beijing, China.
  • Hong Wan
    School of Electrical Engineering, Zhengzhou University, Zhengzhou, Henan, China; Industrial Technology Research Institute, Zhengzhou University, Zhengzhou, Henan, China; Henan Key Laboratory of Brain Science and Brain-Computer Interface Technology, Zhengzhou, Henan, China. Electronic address: wanhong@zzu.edu.cn.
  • Weijun Zhang
    Shanghai United Imaging Healthcare Co., Ltd., Shanghai, China.
  • Yate Huang
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Haigang Jin
    Department of Thyroid & Breast Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.
  • Zhenyu Wang
    Department of Radiology, Affiliated Hospital 6 of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.