AIMC Topic: Immunogenic Cell Death

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Integrative single-cell and machine learning approach to characterize immunogenic cell death and tumor microenvironment in LUAD.

Journal of translational medicine
BACKGROUND: Immunogenic cell death (ICD) triggers antitumor immune responses and plays a critical role in shaping the tumor microenvironment (TME). However, its specific contribution to lung adenocarcinoma (LUAD) progression and immunotherapy respons...

Machine learning-based construction of Immunogenic cell death-related score for improving prognosis and personalized treatment in glioma.

Scientific reports
Immunogenic cell death (ICD) is capable of activating both innate and adaptive immune responses. In this study, we aimed to develop an ICD-related signature in glioma patients and facilitate the assessment of their prognosis and drug sensitivity. Con...

High-throughput screening system for immunogenic cell death inducers using artificial intelligence-based real-time image analysis.

Computers in biology and medicine
Immunogenic cell death (ICD) can enhance the immunogenicity of cold tumors, convert them into immune-responsive hot tumors, and improve the efficacy of cancer immunotherapy. Because ICD inducers cause cell swelling, membrane rupture, and the release ...

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity.

Molecular cancer
BACKGROUND: Immunogenic cell death (ICD) inducers are often identified in phenotypic screening campaigns by the release or surface exposure of various danger-associated molecular patterns (DAMPs) from malignant cells. This study aimed to streamline t...

Multi-omics features of immunogenic cell death in gastric cancer identified by combining single-cell sequencing analysis and machine learning.

Scientific reports
Gastric cancer (GC) is a prevalent malignancy with high mortality rates. Immunogenic cell death (ICD) is a unique form of programmed cell death that is closely linked to antitumor immunity and plays a critical role in modulating the tumor microenviro...

Machine Learning-Driven discovery of immunogenic cell Death-Related biomarkers and molecular classification for diabetic ulcers.

Gene
In this study, we redefine the diagnostic landscape of diabetic ulcers (DUs), a major diabetes complication. Our research uncovers new biomarkers linked to immunogenic cell death (ICD) in DUs by utilizing RNA-sequencing data of Gene Expression Omnibu...

Machine learning-based integration develops an immunogenic cell death-derived lncRNA signature for predicting prognosis and immunotherapy response in lung adenocarcinoma.

Scientific reports
Accumulating evidence demonstrates that lncRNAs are involved in the regulation of the immune microenvironment and early tumor development. Immunogenic cell death occurs mainly through the release or increase of tumor-associated antigen and tumor-spec...

PTPRC promoted CD8+ T cell mediated tumor immunity and drug sensitivity in breast cancer: based on pan-cancer analysis and artificial intelligence modeling of immunogenic cell death-based drug sensitivity stratification.

Frontiers in immunology
BACKGROUND: Immunogenic cell death (ICD) is a result of immune cell infiltration (ICI)-mediated cell death, which is also a novel acknowledgment to regulate cellular stressor-mediated cell death, including drug therapy and radiotherapy.