AIMC Topic: Immunogenic Cell Death

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AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity.

Molecular cancer Dec 20, 2024
BACKGROUND: Immunogenic cell death (ICD) inducers are often identified in phenotypic screening campaigns by the release or surface exposure of various danger-associated molecular patterns (DAMPs) from malignant cells. This study aimed to streamline t...
Humans Artificial Intelligence Animals Neoplasms Antineoplastic Agents Cell Line, Tumor Mice Quantitative Structure-Activity Relationship Cell Nucleolus Immunogenic Cell Death
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Multi-omics features of immunogenic cell death in gastric cancer identified by combining single-cell sequencing analysis and machine learning.

Scientific reports Sep 18, 2024
Gastric cancer (GC) is a prevalent malignancy with high mortality rates. Immunogenic cell death (ICD) is a unique form of programmed cell death that is closely linked to antitumor immunity and plays a critical role in modulating the tumor microenviro...
Humans Machine Learning Stomach Neoplasms Tumor Microenvironment Gene Expression Profiling Transcriptome Single-Cell Analysis Gene Regulatory Networks Computational Biology Multiomics Gene Expression Regulation, Neoplastic Proteomics Immunogenic Cell Death
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Machine Learning-Driven discovery of immunogenic cell Death-Related biomarkers and molecular classification for diabetic ulcers.

Gene Sep 17, 2024
In this study, we redefine the diagnostic landscape of diabetic ulcers (DUs), a major diabetes complication. Our research uncovers new biomarkers linked to immunogenic cell death (ICD) in DUs by utilizing RNA-sequencing data of Gene Expression Omnibu...
Humans Machine Learning Algorithms Biomarkers Diabetic Foot Immunogenic Cell Death
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Machine learning-based integration develops an immunogenic cell death-derived lncRNA signature for predicting prognosis and immunotherapy response in lung adenocarcinoma.

Scientific reports May 22, 2024
Accumulating evidence demonstrates that lncRNAs are involved in the regulation of the immune microenvironment and early tumor development. Immunogenic cell death occurs mainly through the release or increase of tumor-associated antigen and tumor-spec...
Humans Machine Learning Prognosis Tumor Microenvironment Biomarkers, Tumor Lung Neoplasms Immunotherapy Gene Expression Regulation, Neoplastic RNA, Long Noncoding Adenocarcinoma of Lung Immunogenic Cell Death
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PTPRC promoted CD8+ T cell mediated tumor immunity and drug sensitivity in breast cancer: based on pan-cancer analysis and artificial intelligence modeling of immunogenic cell death-based drug sensitivity stratification.

Frontiers in immunology Jun 14, 2023
BACKGROUND: Immunogenic cell death (ICD) is a result of immune cell infiltration (ICI)-mediated cell death, which is also a novel acknowledgment to regulate cellular stressor-mediated cell death, including drug therapy and radiotherapy.
Humans Artificial Intelligence Triple Negative Breast Neoplasms CD8-Positive T-Lymphocytes Drug Resistance Leukocyte Common Antigens Immunogenic Cell Death
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