AIMC Topic: CD8-Positive T-Lymphocytes
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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.
Frontiers in immunology
May 22, 2025
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment...
Tumor Microenvironment
Male
Gene Expression Profiling
Transcriptome
Prognosis
Female
Colorectal Neoplasms
CD8-Positive T-Lymphocytes
Amino Acids
Programmed Cell Death 1 Receptor
Cell Line, Tumor
Tumor Escape
Humans
Single-Cell Analysis
Gene Expression Regulation, Neoplastic
Lymphocytes, Tumor-Infiltrating
MIST: An interpretable and flexible deep learning framework for single-T cell transcriptome and receptor analysis.
Science advances
Apr 4, 2025
Joint analysis of transcriptomic and T cell receptor (TCR) features at single-cell resolution provides a powerful approach for in-depth T cell immune function research. Here, we introduce a deep learning framework for single-T cell transcriptome and ...
Immune profile and routine laboratory indicator-based machine learning for prediction of lung cancer.
Computers in biology and medicine
Mar 31, 2025
INTRODUCTION: Early diagnosis of lung cancer is still a challenge by using current diagnostic methods.
High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC.
Frontiers in immunology
Dec 19, 2024
INTRODUCTION: Tumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits oftheir subpopulations.
Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines.
Nature communications
Nov 28, 2024
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell immunity against current and emerging SARS-CoV-2 variants. Precise identification of conserved T-cell epitopes is critical for designing effective vaccines. He...
A commentary on 'Single-cell and bulk RNA-sequence identified fibroblasts signature and CD8 + T cell - fibroblast subtype predicting prognosis and immune therapeutic response of bladder cancer, based on machine-learning'.
International journal of surgery (London, England)
Sep 1, 2024
Identification of gene and protein signatures associated with long-term effects of COVID-19 on the immune system after patient recovery by analyzing single-cell multi-omics data using a machine learning approach.
Vaccine
Aug 24, 2024
Viral infections significantly impact the immune system, and impact will persist until recovery. However, the influence of severe acute respiratory syndrome coronavirus 2 infection on the homeostatic immune status and secondary immune response in rec...
Integration of Bioinformatics and Machine Learning to Identify CD8+ T Cell-Related Prognostic Signature to Predict Clinical Outcomes and Treatment Response in Breast Cancer Patients.
Genes
Aug 19, 2024
UNLABELLED: The incidence of breast cancer (BC) continues to rise steadily, posing a significant burden on the public health systems of various countries worldwide. As a member of the tumor microenvironment (TME), CD8+ T cells inhibit cancer progress...
Prediction of CD8+T lymphocyte infiltration levels in gastric cancer from contrast-enhanced CT and clinical factors using machine learning.
Medical physics
Aug 17, 2024
BACKGROUND: CD8+ T lymphocyte infiltration is closely associated with the prognosis and immunotherapy response of gastric cancer (GC). For now, the examination of CD8 infiltration levels relies on endoscopic biopsy, which is invasive and unsuitable f...
Single-cell and bulk RNA-sequence identified fibroblasts signature and CD8 + T-cell - fibroblast subtype predicting prognosis and immune therapeutic response of bladder cancer, based on machine learning: bioinformatics multi-omics study.
International journal of surgery (London, England)
Aug 1, 2024
BACKGROUND: Cancer-associated fibroblasts (CAFs) are found in primary and advanced tumours. They are primarily involved in tumour progression through complex mechanisms with other types of cells in the tumour microenvironment. However, essential fibr...
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