Identification of Diagnostic Schizophrenia Biomarkers Based on the Assessment of Immune and Systemic Inflammation Parameters Using Machine Learning Modeling.

Journal: Sovremennye tekhnologii v meditsine
PMID: 39944368

Abstract

UNLABELLED: Disorders of systemic immunity and immune processes in the brain have now been shown to play an essential role in the development and progression of schizophrenia. Nevertheless, only a few works were devoted to the study of some immune parameters to objectify the diagnosis by means of machine learning. At the same time, machine learning methods have not yet been applied to a set of data fully reflecting systemic characteristics of the immune status (parameters of adaptive immunity, the level of inflammatory markers, the content of major cytokines). Considering a complex nature of immune system disorders in schizophrenia, incorporation of a broad panel of immunological data into machine learning models is promising for improving classification accuracy and identifying the parameters reflecting the immune disorders typical for the majority of patients. is to assess the possibility of using immunological parameters to objectify the diagnosis of schizophrenia applying machine learning models.

Authors

  • I K Malashenkova
    MD, PhD, Head of the Laboratory of Molecular Immunology and Virology; National Research Center "Kurchatov Institute", 1 Akademika Kurchatova Square, Moscow, 123182, Russia; Senior Researcher, Laboratory of Clinical Immunology; Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency of Russia, 1A Malaya Pirogovskaya St., Moscow, 119435, Russia.
  • S A Krynskiy
    MD, PhD, Senior Researcher, Laboratory of Molecular Immunology and Virology; National Research Center "Kurchatov Institute", 1 Akademika Kurchatova Square, Moscow, 123182, Russia; Junior Researcher, Department of Mental Disorders in Neurodegenerative Brain Diseases; N.A. Alekseyev Psychiatric Clinical Hospital No.1, 2 Zagorodnoye Shosse, Moscow, 117152, Russia.
  • D P Ogurtsov
    MD, PhD, Senior Researcher, Laboratory of Molecular Immunology and Virology; National Research Center "Kurchatov Institute", 1 Akademika Kurchatova Square, Moscow, 123182, Russia; Researcher, Laboratory of Clinical Immunology; Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency of Russia, 1A Malaya Pirogovskaya St., Moscow, 119435, Russia.
  • N A Khailov
    MD, PhD, Senior Researcher, Resource Center of Molecular and Cell Biology; National Research Center "Kurchatov Institute", 1 Akademika Kurchatova Square, Moscow, 123182, Russia.
  • P V Druzhinina
    PhD Student; Skolkovo Institute of Science and Technology (Skoltech), Territory of Skolkovo Innovation Center, Bldg. 1, 30 Bolshoy Boulevard, Moscow, 121205, Russia; Intern Researcher, Biomedically Informed Artificial Intelligence Laboratory (BIMAI-lab); The University of Sharjah, the United Arab Emirates, Sharjah, 27272.
  • A V Bernstein
    DSc, Professor; Skolkovo Institute of Science and Technology (Skoltech), Territory of Skolkovo Innovation Center, Bldg. 1, 30 Bolshoy Boulevard, Moscow, 121205, Russia.
  • A V Artemov
    PhD, Senior Researcher; Skolkovo Institute of Science and Technology (Skoltech), Territory of Skolkovo Innovation Center, Bldg. 1, 30 Bolshoy Boulevard, Moscow, 121205, Russia.
  • G Sh Mamedova
    Junior Researcher, Laboratory of Fundamental Research Methods; N.A. Alekseyev Psychiatric Clinical Hospital No.1, 2 Zagorodnoye Shosse, Moscow, 117152, Russia.
  • N V Zakharova
    MD, PhD, Head of the Laboratory of Fundamental Research Methods; N.A. Alekseyev Psychiatric Clinical Hospital No.1, 2 Zagorodnoye Shosse, Moscow, 117152, Russia.
  • G P Kostyuk
    MD, DSc, Professor, Head Physician; N.A. Alekseyev Psychiatric Clinical Hospital No.1, 2 Zagorodnoye Shosse, Moscow, 117152, Russia.
  • V L Ushakov
    PhD, Associate Professor, Leading Researcher; Insitute of Perspective Brain Research, M.V. Lomonosov Moscow State University, Bldg. 1, 27 Lomonosov Avenue, Moscow, 119192, Russia; Senior Researcher, Department of Mental Disorders in Neurodegenerative Brain Diseaseas; N.A. Alekseyev Psychiatric Clinical Hospital No.1, 2 Zagorodnoye Shosse, Moscow, 117152, Russia; Senior Researcher; National Research Nuclear University MEPhI, 31 Kashirskoye Shosse, Moscow, 115409, Russia.
  • M G Sharaev
    Senior Teacher; Skolkovo Institute of Science and Technology (Skoltech), Territory of Skolkovo Innovation Center, Bldg. 1, 30 Bolshoy Boulevard, Moscow, 121205, Russia; Head of the Biomedically Informed Artificial Intelligence Laboratory (BIMAI-lab); The University of Sharjah, the United Arab Emirates, Sharjah, 27272; Senior Researcher, Department of Mental Disorders in Neurodegenerative Brain Diseases; N.A. Alekseyev Psychiatric Clinical Hospital No.1, 2 Zagorodnoye Shosse, Moscow, 117152, Russia.

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