Accurate stratification between VEXAS syndrome and differential diagnoses by deep learning analysis of peripheral blood smears.
Journal:
Clinical chemistry and laboratory medicine
Published Date:
Jun 27, 2023
Abstract
OBJECTIVES: VEXAS syndrome is a newly described autoinflammatory disease associated with somatic mutations and vacuolization of myeloid precursors. This disease possesses an increasingly broad spectrum, leading to an increase in the number of suspected cases. Its diagnosis via bone-marrow aspiration and -gene sequencing is time-consuming and expensive. This study aimed at analyzing peripheral leukocytes using deep learning approaches to predict VEXAS syndrome in comparison to differential diagnoses.