Expert-Level Immunofixation Electrophoresis Image Recognition based on Explainable and Generalizable Deep Learning.

Journal: Clinical chemistry
PMID:

Abstract

BACKGROUND: Immunofixation electrophoresis (IFE) is important for diagnosis of plasma cell disorders (PCDs). Manual analysis of IFE images is time-consuming and potentially subjective. An artificial intelligence (AI) system for automatic and accurate IFE image recognition is desirable.

Authors

  • Honghua Hu
    Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
  • Wei Xu
    College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, 471023 China.
  • Ting Jiang
    School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China.
  • Yuheng Cheng
    Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
  • Xiaoyan Tao
    Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
  • Wenna Liu
    Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
  • Meiling Jian
    Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
  • Kang Li
    Department of Otolaryngology, Longgang Otolaryngology hospital & Shenzhen Key Laboratory of Otolaryngology, Shenzhen Institute of Otolaryngology, Shenzhen, Guangdong, China.
  • Guotai Wang
    Wellcome / EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, UK.