AIMC Topic: Paraproteinemias

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Machine learning reveals distinct T-cell receptor clusters in plasma cell dyscrasias compared to healthy controls.

PloS one
T-cell receptor (TCR) repertoire diversity has been implicated in the progression and prognosis of multiple myeloma (MM). This study aimed to evaluate the association between T-cell clonality, immune response, and clinical outcomes in patients with p...

Common laboratory results-based artificial intelligence analysis achieves accurate classification of plasma cell dyscrasias.

PeerJ
BACKGROUND: Plasma cell dyscrasias encompass a diverse set of disorders, where early and precise diagnosis is essential for optimizing patient outcomes. Despite advancements, current diagnostic methodologies remain underutilized in applying artificia...

Accurate classification of plasma cell dyscrasias is achieved by combining artificial intelligence and flow cytometry.

British journal of haematology
Monoclonal gammopathy of unknown significance (MGUS), smouldering multiple myeloma (SMM), and multiple myeloma (MM) are very common neoplasms. However, it is often difficult to distinguish between these entities. In the present study, we aimed to cla...

Expert-Level Immunofixation Electrophoresis Image Recognition based on Explainable and Generalizable Deep Learning.

Clinical chemistry
BACKGROUND: Immunofixation electrophoresis (IFE) is important for diagnosis of plasma cell disorders (PCDs). Manual analysis of IFE images is time-consuming and potentially subjective. An artificial intelligence (AI) system for automatic and accurate...