Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging.

Journal: Materials science & engineering. C, Materials for biological applications
PMID: 29519419

Abstract

Curcumin (Curc) reacts with zinc di‑iodine (ZnI) in 2:1molar ratio in the presence of an excess of a base triethylamine ((CHCH)N) in methanol (CHOH) solution towards the amorphous solid material of formula [ZnI(Curc)] (1). The complex was characterized by melting point (m.p.), Fourier Transform-Infra Red (FT-IR) and Nuclear Magnetic Resonance of hydrogen nucleus (H NMR) spectroscopy. The formula of 1 was determined by X-ray fluorescence (XRF) analysis. The retention of the structure in solution was confirmed by H NMR spectroscopy. The antimicrobial activity of the complex has been studied against the bacteria Pseudomonas aeruginosa (PAO1). The Minimum Inhibitory Concentrations (MIC) of the compounds 1 and Curc against P. aeruginosa (PAO1) are: 71.3μΜ (75.3μg/mL) for [ZnI(Curc)] and 339μM (125μg/mL) for Curc, respectively. Moreover, the antimicrobial activity of the new material which was diffused in polystyrene against biofilm formed by PAO1 was also calculated.

Authors

  • A Papadimitriou
    Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece; Department of Materials Science and Engineering, University of Ioannina, Greece.
  • I Ketikidis
    Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
  • M-E K Stathopoulou
    Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
  • C N Banti
    Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. Electronic address: cbanti@cc.uoi.gr.
  • C Papachristodoulou
    Department of Physics, University of Ioannina, Greece.
  • L Zoumpoulakis
    Department of Chemical Engineering, NTUA, 15780 Athens, Greece.
  • S Agathopoulos
    Department of Materials Science and Engineering, University of Ioannina, Greece.
  • G V Vagenas
    GCSL, Chemical Service of Epirus & Western Macedonia, 30 Dompoli str., 45332 Ioannina, Greece.
  • S K Hadjikakou
    Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. Electronic address: shadjika@uoi.gr.

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