Subcutaneous cefazolin to reduce surgical site infections in a porcine model.

Journal: The Journal of surgical research
Published Date: Dec 28, 2017

Abstract

BACKGROUND: Surgical site infections (SSIs) pose a significant health and financial burden. A key aspect of appropriate prophylaxis is the administration of antibiotics intravenously (IV). However, subcutaneous administration of antibiotics is not well described in the literature. During surgery, we hypothesize that subcutaneous injection may provide better protection against SSIs. To better understand the kinetics after subcutaneous injection, we describe the serum concentrations of cefazolin in a porcine model.

Authors

  • Genia Dubrovsky
    Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
  • Nhan Huynh
    Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
  • Joshua D Rouch
    Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
  • John P Koulakis
    Department of Physics and Astronomy, University of California-Los Angeles, Los Angeles, California.
  • David P Nicolau
    Hartford Hospital, Center for Anti-Infective Research and Development, Hartford, Connecticut.
  • Christina A Sutherland
    Hartford Hospital, Center for Anti-Infective Research and Development, Hartford, Connecticut.
  • Seth Putterman
    Department of Physics and Astronomy, University of California-Los Angeles, Los Angeles, California.
  • James C Y Dunn
    Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Division of Pediatric Surgery, Department of Surgery, Stanford University, Stanford, California. Electronic address: jdunn2@stanford.edu.

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