Effect of the vascularized bone components on the survival of vascularized composite allografts.

Journal: The Journal of surgical research
Published Date: Apr 6, 2017

Abstract

BACKGROUND: Vascularized composite allograft (VCA), such as hand and face allograft, contains a vascularized bone component that may provide an immunologic benefit and induce tolerance for the simultaneous inclusion of marrow cells and a marrow microenvironment. We developed a chimeric groin cutaneous/femur flap to investigate the effect of vascularized bone marrow on VCA survival and its ability to induce chimerism.

Authors

  • Jianwu Chen
    Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Plastic Surgery, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, China.
  • Dongliang Zhang
    School of Agricultural Engineering and Food Science, Shandong University of Technology, Zhangdian District, No. 12, Zhangzhou Road, Zibo, Shandong Province, China.
  • Tao Zhang
    Department of Traumatology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, 40044, People's Republic of China.
  • Chen Chen
    The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • Yajuan Song
    Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Shiqiang Liu
    Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Yingjun Su
    Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address: xjzxips@163.com.
  • Shuzhong Guo
    Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address: xjzxips@163.com.

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