AIMC Topic: Graft Survival
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Pancreas rejection: quieting the storm to preserve graft function.
Current opinion in organ transplantation
Apr 23, 2025
PURPOSE OF REVIEW: Allograft rejection remains enigmatic and elusive following pancreas transplantation. In the absence of early technical pancreas graft failure, pancreas allograft rejection is the major cause of death-censored pancreas graft loss b...
Urinary biomarkers of kidney transplant rejection.
Current opinion in organ transplantation
Apr 2, 2025
PURPOSE OF REVIEW: Despite the introduction of many new immunosuppressive medications, allograft rejection remains a significant complication in transplantation. The use of "liquid biopsy" to evaluate allograft function and detect early rejection has...
Advanced prognostic modeling with deep learning: assessing long-term outcomes in liver transplant recipients from deceased and living donors.
Journal of translational medicine
Feb 16, 2025
BACKGROUND: Predicting long-term outcomes in liver transplantation remain a challenging endeavor. This research aims to harness the power of deep learning to develop an advanced prognostic model for assessing long-term outcomes, with a specific focus...
Developing approaches to incorporate donor-lung computed tomography images into machine learning models to predict severe primary graft dysfunction after lung transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Feb 7, 2025
Primary graft dysfunction (PGD) is a common complication after lung transplantation associated with poor outcomes. Although risk factors have been identified, the complex interactions between clinical variables affecting PGD risk are not well underst...
Developing clinical prognostic models to predict graft survival after renal transplantation: comparison of statistical and machine learning models.
BMC medical informatics and decision making
Feb 3, 2025
INTRODUCTION: Renal transplantation is a critical treatment for end-stage renal disease, but graft failure remains a significant concern. Accurate prediction of graft survival is crucial to identify high-risk patients. This study aimed to develop pro...
Artificial intelligence assisted risk prediction in organ transplantation: a UK Live-Donor Kidney Transplant Outcome Prediction tool.
Renal failure
Jan 21, 2025
Predicting the outcome of a kidney transplant involving a living donor advances donor decision-making donors for clinicians and patients. However, the discriminative or calibration capacity of the currently employed models are limited. We set out to...
Assessing donor kidney function: the role of CIRBP in predicting delayed graft function post-transplant.
Frontiers in immunology
Jan 17, 2025
INTRODUCTION: Delayed graft function (DGF) shortens the survival time of transplanted kidneys and increases the risk of rejection. Current methods are inadequate in predicting DGF. More precise tools are required to assess kidney suitability for tran...
Machine Learning Algorithms in Controlled Donation After Circulatory Death Under Normothermic Regional Perfusion: A Graft Survival Prediction Model.
Transplantation
Jan 9, 2025
BACKGROUND: Several scores have been developed to stratify the risk of graft loss in controlled donation after circulatory death (cDCD). However, their performance is unsatisfactory in the Spanish population, where most cDCD livers are recovered usin...
Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA sequencing and molecular docking.
Renal failure
Dec 4, 2024
Post-transplant allograft fibrosis remains a challenge in prolonging allograft survival. Regulated cell death has been widely implicated in various kidney diseases, including renal fibrosis. However, the role of different regulated cell death (RCD) ...
Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing.
PloS one
Nov 27, 2024
BACKGROUND: The demographic shift towards an older population presents significant challenges for kidney transplantation (KTx), particularly due to the vulnerability of aged donor kidneys to ischemic damage, delayed graft function, and reduced graft ...
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