ChampKit: A framework for rapid evaluation of deep neural networks for patch-based histopathology classification.

Journal: Computer methods and programs in biomedicine
PMID:

Abstract

BACKGROUND AND OBJECTIVE: Histopathology is the gold standard for diagnosis of many cancers. Recent advances in computer vision, specifically deep learning, have facilitated the analysis of histopathology images for many tasks, including the detection of immune cells and microsatellite instability. However, it remains difficult to identify optimal models and training configurations for different histopathology classification tasks due to the abundance of available architectures and the lack of systematic evaluations. Our objective in this work is to present a software tool that addresses this need and enables robust, systematic evaluation of neural network models for patch classification in histology in a light-weight, easy-to-use package for both algorithm developers and biomedical researchers.

Authors

  • Jakub R Kaczmarzyk
    Medical Scientist Training Program, Stony Brook University School of Medicine, Stony Brook, NY, USA.
  • Rajarsi Gupta
    Department of Biomedical Informatics, Stony Brook Medicine, Stony Brook, NY 11794, USA; Department of Pathology, Stony Brook Medicine, Stony Brook, NY 11794, USA.
  • Tahsin M Kurc
    Department of Biomedical Informatics, Stony Brook Medicine, 101 Nicolls Rd, Stony Brook, 11794, NY, USA.
  • Shahira Abousamra
    Department of Computer Science, Stony Brook University, Stony Brook, New York.
  • Joel H Saltz
  • Peter K Koo
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, United States.