Role of α-fetoprotein in differentiation of regulatory T lymphocytes.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
PMID: 29299806

Abstract

The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4 cells. In the study of Treg differentiation, it was found that AFP at concentrations of 50 and 100 μg/mL significantly inhibited the number of nonproliferating CD4FOXP3 and CD4FOXP3HELIOS lymphocytes without affecting the expression of Treg markers by proliferating CD4 lymphocytes.

Authors

  • V A Chereshnev
    Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.
  • V P Timganova
    Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia. timganovavp@gmail.com.
  • S A Zamorina
    Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.
  • M S Bochkova
    Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.
  • P V Khramtsov
    Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.
  • M D Kropaneva
    Perm State National Research University, Perm, Russia.
  • M B Raev
    Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia.

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