AIMC Topic: T-Lymphocytes, Regulatory

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Regulatory T cells and matrix-producing cancer associated fibroblasts contribute on the immune resistance and progression of prognosis related tumor subtypes in ccRCC.

Scientific reports Jul 1, 2025
Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor in the field of urology. The effect of cell heterogeneity on the prognosis and reaction to treatment of ccRCC in large populations is still unclear. By analyzing public single cel...
Gene Expression Regulation, Neoplastic Signal Transduction Prognosis Cancer-Associated Fibroblasts Tumor Microenvironment Humans Carcinoma, Renal Cell Disease Progression T-Lymphocytes, Regulatory Kidney Neoplasms
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Machine learning-assisted decoding of temporal transcriptional dynamics via fluorescent timer.

Nature communications Jul 1, 2025
Investigating the temporal dynamics of gene expression is crucial for understanding gene regulation across various biological processes. Using the Fluorescent Timer protein, the Timer-of-cell-kinetics-and-activity system enables analysis of transcrip...
Mice Mice, Inbred C57BL CRISPR-Cas Systems Flow Cytometry Neural Networks, Computer Forkhead Transcription Factors Enhancer Elements, Genetic Machine Learning Spleen Genes, Reporter Animals T-Lymphocytes, Regulatory Transcription, Genetic Single-Cell Analysis Gene Expression Regulation
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Unveiling the power of Treg.Sig: a novel machine-learning derived signature for predicting ICI response in melanoma.

Frontiers in immunology Mar 28, 2025
BACKGROUND: Although immune checkpoint inhibitor (ICI) represents a significant breakthrough in cancer immunotherapy, only a few patients benefit from it. Given the critical role of Treg cells in ICI treatment resistance, we explored a Treg-associate...
Humans Machine Learning Melanoma Immune Checkpoint Inhibitors Mice Gene Expression Regulation, Neoplastic T-Lymphocytes, Regulatory Animals Gene Expression Profiling Transcriptome Drug Resistance, Neoplasm STAT1 Transcription Factor
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Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients.

International journal of molecular sciences Oct 12, 2021
Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult...
Receptors, Chemokine T-Lymphocytes, Regulatory T-Lymphocyte Subsets B-Lymphocyte Subsets ROC Curve Monocytes Psoriasis Area Under Curve Discriminant Analysis Diagnosis, Differential Arthritis, Psoriatic Aged Adult Middle Aged Machine Learning Phenotype Female Humans
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Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning.

Frontiers in immunology Jun 28, 2021
Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being investigated. Here, we explored the role of CCR5 and its ligands across the immunologic spectrum of CO...
Humans Machine Learning Prognosis Female COVID-19 Algorithms CD8-Positive T-Lymphocytes Post-Acute COVID-19 Syndrome Case-Control Studies RNA, Viral Chemokine CCL5 Lymphocyte Activation T-Lymphocytes, Regulatory SARS-CoV-2 Antibodies, Viral Male Computational Biology Receptors, CCR5 Severity of Illness Index
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Role of α-fetoprotein in differentiation of regulatory T lymphocytes.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections Jan 4, 2018
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-prolife...
Cell Differentiation Humans alpha-Fetoproteins Adult T-Lymphocytes, Regulatory Cells, Cultured Cell Proliferation Female
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[Effect of moxa-cone moxibustion at lung's back- points and front- points on Th17/Treg balance in mice with asthma].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion Nov 12, 2020
OBJECTIVE: To observe the effect of moxa-cone moxibustion at lung's back- points and front- points on the expression of helper T lymphocyte 17 (Th 17)/regulatory T lymphocyte (Treg) in mice with asthma, and to explore the possible mechanism of moxa-c...
T-Lymphocytes, Regulatory Lung Th17 Cells Asthma Mice Animals Moxibustion Male
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[Prophylactic administration of all-trans retinoic acid alleviates inflammation in rats with collagen-induced arthritis].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Feb 20, 2016
OBJECTIVE: To investigate the effects of prophylactic administration of all-trans retinoic acid (ATRA) in relieving inflammation in a rat model of collagen-induced arthritis (CIA).
ADAMTS4 Protein Freund's Adjuvant Interleukin-10 Tretinoin Matrix Metalloproteinase 3 Tumor Necrosis Factor-alpha Th17 Cells Female Arthritis, Experimental Rats Animals Lipids Collagen Type II Inflammation Interleukin-17 T-Lymphocytes, Regulatory Rats, Wistar
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