Regulatory T cells are a class of T lymphocytes which respond to activation signals by expanding their cell numbers, and whose culturing and expansion are of significant clinical interest. Cellular activation states are used to inform process control...
The development of the immune system (ISD) plays a pivotal role in both the genesis and progression of tumors, yet its specific functions in hepatocellular carcinoma (HCC) and the mechanisms behind sorafenib resistance remain elusive. In our investig...
Idiopathic membranous nephropathy (IMN) is the major cause of autoimmune-related nephrotic syndrome. The role immune cells play in the risk and prognosis of IMN remains elusive. We employ multi-omics data and a variety of approaches to evaluate the c...
Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor in the field of urology. The effect of cell heterogeneity on the prognosis and reaction to treatment of ccRCC in large populations is still unclear. By analyzing public single cel...
Investigating the temporal dynamics of gene expression is crucial for understanding gene regulation across various biological processes. Using the Fluorescent Timer protein, the Timer-of-cell-kinetics-and-activity system enables analysis of transcrip...
BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies with poor clinical outcome. Regulatory T cells (Tregs) have a dual role in maintaining immune homeostasis and suppressing anti-tumor immunity. The role of Tregs re...
BACKGROUND: Although immune checkpoint inhibitor (ICI) represents a significant breakthrough in cancer immunotherapy, only a few patients benefit from it. Given the critical role of Treg cells in ICI treatment resistance, we explored a Treg-associate...
International journal of molecular sciences
Oct 12, 2021
Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult...
Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being investigated. Here, we explored the role of CCR5 and its ligands across the immunologic spectrum of CO...
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
Jan 4, 2018
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-prolife...
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