A simulative deep learning model of SNP interactions on chromosome 19 for predicting Alzheimer's disease risk and rates of disease progression.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published Date:

Abstract

BACKGROUND: Identifying genetic patterns that contribute to Alzheimer's disease (AD) is important not only for pre-symptomatic risk assessment but also for building personalized therapeutic strategies.

Authors

  • Jinhyeong Bae
    Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: jinhyeongbae2017@u.northwestern.edu.
  • Paige E Logan
    Department of Neurology, School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Dominic J Acri
    Department of Medical and Molecular Genetics, School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Apoorva Bharthur
    Department of Neurology, School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Kwangsik Nho
    Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Andrew J Saykin
    Indiana University, Indianapolis, IN 46202, USA.
  • Shannon L Risacher
    Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Kelly Nudelman
    Department of Medical and Molecular Genetics, School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Angelina J Polsinelli
    Department of Neurology, School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Valentin Pentchev
    Department of Information Technology, Indiana University Network Science Institute, Bloomington, Indiana, USA.
  • Jungsu Kim
    Department of Medicine, University of California San Diego, La Jolla, CA 92039, USA.
  • Dustin B Hammers
    Department of Neurology, School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Liana G Apostolova
    Department of Neurology, School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.