Preoperative Discrimination of CDKN2A/B Homozygous Deletion Status in Isocitrate Dehydrogenase-Mutant Astrocytoma: A Deep Learning-Based Radiomics Model Using MRI.

Journal: Journal of magnetic resonance imaging : JMRI
PMID: 37555723

Abstract

BACKGROUND: Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion has been verified as an independent and critical biomarker of negative prognosis and short survival in isocitrate dehydrogenase (IDH)-mutant astrocytoma. Therefore, noninvasive and accurate discrimination of CDKN2A/B homozygous deletion status is essential for the clinical management of IDH-mutant astrocytoma patients.

Authors

  • Jueni Gao
    Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Zhi Liu
  • Hongyu Pan
    College of Plant Sciences, Jilin University, Changchun, P. R. China.
  • Xu Cao
  • Yubo Kan
    School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Zhipeng Wen
    Department of Radiology, Sichuan Cancer Hospital, Chengdu, China.
  • Shanxiong Chen
  • Ming Wen
    College of Chemistry and Chemical Engineering, Central South University, Changsha, People's Republic of China.
  • Liqiang Zhang
    Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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