AIMC Topic: Sequence Deletion

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Preoperative Discrimination of CDKN2A/B Homozygous Deletion Status in Isocitrate Dehydrogenase-Mutant Astrocytoma: A Deep Learning-Based Radiomics Model Using MRI.

Journal of magnetic resonance imaging : JMRI Aug 9, 2023
BACKGROUND: Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion has been verified as an independent and critical biomarker of negative prognosis and short survival in isocitrate dehydrogenase (IDH)-mutant astrocytoma. Therefore, non...
Cyclin-Dependent Kinase Inhibitor p16 Isocitrate Dehydrogenase Astrocytoma Sequence Deletion Homozygote Deep Learning Magnetic Resonance Imaging Retrospective Studies Radiomics Humans
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A novel MRI-based deep learning networks combined with attention mechanism for predicting CDKN2A/B homozygous deletion status in IDH-mutant astrocytoma.

European radiology Aug 8, 2023
OBJECTIVES: To develop a high-accuracy MRI-based deep learning method for predicting cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion status in isocitrate dehydrogenase (IDH)-mutant astrocytoma.
Deep Learning Glioma Humans Brain Neoplasms Mutation Isocitrate Dehydrogenase Homozygote Magnetic Resonance Imaging Cyclin-Dependent Kinase Inhibitor p16 Astrocytoma Sequence Deletion
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Editorial for "Preoperative Discrimination of CDKN2A/B Homozygous Deletion Status in Isocitrate Dehydrogenase-Mutant Astrocytoma: A Deep Learning-Based Radiomics Model Using MRI".

Journal of magnetic resonance imaging : JMRI Jun 12, 2023
Isocitrate Dehydrogenase Cyclin-Dependent Kinase Inhibitor p16 Homozygote Deep Learning Mutation Sequence Deletion Radiomics Magnetic Resonance Imaging Humans Brain Neoplasms Astrocytoma
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Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Mar 9, 2020
INTRODUCTION: Histologic subtypes of malignant pleural mesothelioma are a major prognostic indicator and decision denominator for all therapeutic strategies. In an ambiguous case, a rare transitional mesothelioma (TM) pattern may be diagnosed by path...
Sequence Deletion Ubiquitin Thiolesterase Tumor Suppressor Proteins Homozygote Lung Neoplasms Mesothelioma Humans Deep Learning
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DeepSV: accurate calling of genomic deletions from high-throughput sequencing data using deep convolutional neural network.

BMC bioinformatics Dec 12, 2019
BACKGROUND: Calling genetic variations from sequence reads is an important problem in genomics. There are many existing methods for calling various types of variations. Recently, Google developed a method for calling single nucleotide polymorphisms (...
Genomics Humans High-Throughput Nucleotide Sequencing Machine Learning Neural Networks, Computer Sequence Deletion Base Sequence Software Chromosomes, Human
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Prediction of sgRNA on-target activity in bacteria by deep learning.

BMC bioinformatics Oct 24, 2019
BACKGROUND: One of the main challenges for the CRISPR-Cas9 system is selecting optimal single-guide RNAs (sgRNAs). Recently, deep learning has enhanced sgRNA prediction in eukaryotes. However, the prokaryotic chromatin structure is different from euk...
Gene Editing Bacteria Neural Networks, Computer RNA, Guide, CRISPR-Cas Systems CRISPR-Cas Systems Sequence Deletion Deep Learning
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Medical Statistics Unlock the Gateway to Further Research: Using Deep Learning to Predict CDKN2A/B Homozygous Deletion in Isocitrate Dehydrogenase-Mutant Astrocytoma.

Korean journal of radiology Dec 1, 2023
Astrocytoma Sequence Deletion Deep Learning Magnetic Resonance Imaging Cyclin-Dependent Kinase Inhibitor p16 Humans Isocitrate Dehydrogenase Public Health Homozygote
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Response to "Medical Statistics Unlock the Gateway to Further Research: Using Deep Learning to Predict CDKN2A/B Homozygous Deletion in Isocitrate Dehydrogenase-Mutant Astrocytoma".

Korean journal of radiology Dec 1, 2023
Humans Public Health Deep Learning Homozygote Cyclin-Dependent Kinase Inhibitor p16 Astrocytoma Sequence Deletion Isocitrate Dehydrogenase
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