Towards Building a Trustworthy Deep Learning Framework for Medical Image Analysis.

Journal: Sensors (Basel, Switzerland)
Published Date:

Abstract

Computer vision and deep learning have the potential to improve medical artificial intelligence (AI) by assisting in diagnosis, prediction, and prognosis. However, the application of deep learning to medical image analysis is challenging due to limited data availability and imbalanced data. While model performance is undoubtedly essential for medical image analysis, model trust is equally important. To address these challenges, we propose TRUDLMIA, a trustworthy deep learning framework for medical image analysis, which leverages image features learned through self-supervised learning and utilizes a novel surrogate loss function to build trustworthy models with optimal performance. The framework is validated on three benchmark data sets for detecting pneumonia, COVID-19, and melanoma, and the created models prove to be highly competitive, even outperforming those designed specifically for the tasks. Furthermore, we conduct ablation studies, cross-validation, and result visualization and demonstrate the contribution of proposed modules to both model performance (up to 21%) and model trust (up to 5%). We expect that the proposed framework will support researchers and clinicians in advancing the use of deep learning for dealing with public health crises, improving patient outcomes, increasing diagnostic accuracy, and enhancing the overall quality of healthcare delivery.

Authors

  • Kai Ma
    Tencent Jarvis Lab, Shenzhen, 518057, China.
  • Siyuan He
    Faculty of Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
  • Grant Sinha
    Faculty of Mathematics, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
  • Ashkan Ebadi
    Department of Biomedical Engineering, University of Florida, Gainesville, USA.
  • Adrian Florea
    Department of Emergency Medicine, McGill University, Montreal, QC H4A 3J1, Canada.
  • Stéphane Tremblay
    Digital Technologies Research Centre, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.
  • Alexander Wong
    Department of Systems Design Engineering, University of Waterloo, Waterloo, ON, Canada.
  • Pengcheng Xi
    Department of Systems Design Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.