Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer.

Journal: Clinical breast cancer
Published Date: Dec 11, 2017

Abstract

INTRODUCTION: There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitamin D levels during neoadjuvant chemotherapy (NAC) on the rates of achieving pathologic complete response (pCR) after breast cancer NAC.

Authors

  • Akiko Chiba
    Division of Surgical Oncology, Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
  • Rachna Raman
    Bon Secours Richmond Heath System, Richmond, VA.
  • Alexandra Thomas
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
  • Pierre-Jean Lamy
    Department of Medical Oncology, Institut Régional Du Cancer de Montpellier ICM, Montpellier, France.
  • Marie Viala
    Department of Medical Oncology, Institut Régional Du Cancer de Montpellier ICM, Montpellier, France.
  • Stephane Pouderoux
    Department of Medical Oncology, Institut Régional Du Cancer de Montpellier ICM, Montpellier, France.
  • Sarah L Mott
    Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA.
  • Mary C Schroeder
    College of Pharmacy, University of Iowa, Iowa City, IA.
  • Simon Thezenas
    Biometry Unit, Institut Régional Du Cancer de Montpellier ICM, Montpellier, France.
  • William Jacot
    Department of Medical Oncology, Institut Régional Du Cancer de Montpellier ICM, Montpellier, France. Electronic address: william.jacot@icm.unicancer.fr.

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