Bacteria from bronchoalveolar lavage fluid from children with suspected chronic lower respiratory tract infection: results from a multi-center, cross-sectional study in Spain.

Journal: European journal of pediatrics
PMID: 29285648

Abstract

UNLABELLED: This cross-sectional study assessed the prevalence of bacteria isolated from Spanish children with suspected chronic lower respiratory tract infection (LRTI) for whom bronchoalveolar lavage (BAL) was indicated. BAL fluid (BALF) was collected from 191 children (aged ≥ 6 months to < 6 years, with persistent or recurrent respiratory symptoms, non-responders to usual treatment) and cultured. Nasopharyngeal swabs (NPSs) were also obtained and cultured to assess concordance of BALF and NPS findings in the same patient. Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis were identified from BALF with a bacterial load indicative of infection (> 10 colony-forming units/mL) in 10.5, 8.9, and 6.3% of children, respectively. Clinical characteristics were similar among participants, regardless of positivity status for any of the bacteria. Approximately 26% of pneumococcal isolates were PCV13 serotypes, and 96% of H. influenzae isolates were non-typeable (NTHi). Concordance between BALF and NPS isolates was 51.0% for S. pneumoniae, 52.1% for H. influenzae, and 22.0% for M. catarrhalis.

Authors

  • Amparo Escribano Montaner
    Pediatric Pneumology and Cystic Fibrosis Unit, University Clinic Hospital of Valencia, University of Valencia, Av. de Blasco Ibáñez, 13, 46010, Valencia, Spain.
  • Juan García de Lomas
    Department of Microbiology, School of Medicine and University Hospital, University of Valencia, Av. de Blasco Ibañez 17, 46010, Valencia, Spain.
  • José Ramón Villa Asensi
    Pediatric Department, Niño Jesús University Hospital for Children, Calle Menéndez Pelayo, 65, 28009, Madrid, Spain.
  • Oscar Asensio de la Cruz
    Pediatric Pulmonology Unit, University Hospital Parc Tauli de Sabadell, Parc Taulí, 1, 08208, Sabadell, Barcelona, Spain.
  • Olga de la Serna Blázquez
    Pediatric Department, Hospital La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain.
  • Mikel Santiago Burruchaga
    Pediatric Pneumology and Cystic Fibrosis Unit, Cruces University Hospital, Plaza de Cruces, S/N, 48903, Baracaldo, Vizcaya, Spain.
  • Pedro Mondéjar López
    Pediatric Pulmonology and Cystic Fibrosis Unit, Virgen of Arrixaca University Hospital, Ctra. Madrid-Cartagena, s/n, 30120, El Palmar, Murcia, Spain.
  • Alba Torrent Vernetta
    Paediatric Pulmonology and Cystic Fibrosis Unit, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
  • Yang Feng
    Computational Health Research Branch, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
  • Melissa K Van Dyke
    GSK, Collegeville, 1250 S Collegeville Rd, Collegeville, PA, 19426, USA.
  • Janet Reyes
    GSK, Parque Tecnológico de Madrid, Calle de Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain.
  • Pilar Garcia-Corbeira
    GSK, Parque Tecnológico de Madrid, Calle de Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain.
  • Carla A Talarico
    GSK, Av. Fleming 20, 1300, Wavre, Belgium. carla.a.talarico@gsk.com.

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