An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning.

Journal: The Journal of allergy and clinical immunology
PMID:

Abstract

BACKGROUND: Diagnostic evaluation of eosinophilic esophagitis (EoE) remains difficult, particularly the assessment of the patient's allergic status.

Authors

  • Benjamin F Sallis
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass.
  • Lena Erkert
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass.
  • Sherezade MoƱino-Romero
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  • Utkucan Acar
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass.
  • Rina Wu
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass.
  • Liza Konnikova
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass.
  • Willem S Lexmond
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass.
  • Matthew J Hamilton
    Department of Medicine, Harvard Medical School, Boston, Mass; Department of Pathology, Brigham and Women's Hospital, Boston, Mass; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Mass.
  • W Augustine Dunn
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass.
  • Zsolt Szepfalusi
    Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
  • Jon A Vanderhoof
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass.
  • Scott B Snapper
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Jerrold R Turner
    Department of Pathology, Brigham and Women's Hospital, Boston, Mass; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Mass.
  • Jeffrey D Goldsmith
    Department of Pathology, Boston Children's Hospital, Boston, Mass.
  • Lisa A Spencer
    Department of Medicine, Harvard Medical School, Boston, Mass; Department of Medicine, Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Boston, Mass.
  • Samuel Nurko
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass.
  • Edda Fiebiger
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass. Electronic address: edda.fiebiger@childrens.harvard.edu.