Exhaled breath condensate metabolome clusters for endotype discovery in asthma.

Journal: Journal of translational medicine
Published Date: Dec 22, 2017

Abstract

BACKGROUND: Asthma is a complex, heterogeneous disorder with similar presenting symptoms but with varying underlying pathologies. Exhaled breath condensate (EBC) is a relatively unexplored matrix which reflects the signatures of respiratory epithelium, but is difficult to normalize for dilution.

Authors

  • Anirban Sinha
    Department of Lung Disease, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
  • Koundinya Desiraju
    Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrated Biology, Mall Road, Delhi, 110007, India.
  • Kunal Aggarwal
    Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrated Biology, Mall Road, Delhi, 110007, India.
  • Rintu Kutum
    Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrated Biology, Mall Road, Delhi, 110007, India.
  • Siddhartha Roy
    CSIR-Indian Institute of Chemical Biology, Kolkata, India.
  • Rakesh Lodha
    Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • S K Kabra
    Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Balaram Ghosh
    Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrated Biology, Mall Road, Delhi, 110007, India.
  • Tavpritesh Sethi
    Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. tavpriteshsethi@iiitd.ac.in.
  • Anurag Agrawal
    Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrated Biology, Mall Road, Delhi, 110007, India. a.agrawal@igib.in.

Keywords

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