The Medical Action Ontology: A tool for annotating and analyzing treatments and clinical management of human disease.

Journal: Med (New York, N.Y.)
Published Date:

Abstract

BACKGROUND: Navigating the clinical literature to determine the optimal clinical management for rare diseases presents significant challenges. We introduce the Medical Action Ontology (MAxO), an ontology specifically designed to organize medical procedures, therapies, and interventions.

Authors

  • Leigh C Carmody
    Monarch Initiative (monarchinitiative.org).
  • Michael A Gargano
    The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Sabrina Toro
    Zebrafish Information Network, University of Oregon, Eugene, OR, USA.
  • Nicole A Vasilevsky
    Ontology Development Group, Library, Oregon Health and Science University, Portland, Oregon, 97239, USA.
  • Margaret P Adam
    Department of Pediatrics, University of Washington, Seattle, Washington, USA.
  • Hannah Blau
    Monarch Initiative, monarchinitiative.org.
  • Lauren E Chan
    Oregon State University, Corvallis, OR, 97331, USA. chanl@oregonstate.edu.
  • David Gómez-Andrés
    Child Neurology Unit. Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
  • Rita Horvath
    Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 0PY, UK.
  • Megan L Kraus
    University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Markus S Ladewig
    Department of Ophthalmology, Klinikum Saarbrücken, Saarbrücken, Germany.
  • David Lewis-Smith
    Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Hanns Lochmüller
    John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Institute of Genetic Medicine, University of Newcastle, Newcastle upon Tyne, UK.
  • Nicolas A Matentzoglu
    Semanticly, Athens, Attiki, Greece.
  • Monica C Munoz-Torres
    Monarch Initiative.
  • Catharina Schuetz
    Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
  • Berthold Seitz
    Department of Ophthalmology, Saarland University Medical Center UKS, Homburg, Saar, Germany.
  • Morgan N Similuk
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Teresa N Sparks
    Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Timmy Strauss
    Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
  • Emilia M Swietlik
    Department of Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge CB2 0BB, UK.
  • Rachel Thompson
    John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Institute of Genetic Medicine, University of Newcastle, Newcastle upon Tyne, UK.
  • Xingmin Aaron Zhang
    The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Christopher J Mungall
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  • Melissa A Haendel
    Library, Oregon Health & Science University, Portland, OR 97239, USA.
  • Peter N Robinson
    The Jackson Laboratory for Genomic Medicine Farmington CT 06032 USA.