Deep learning-based 3D brain multimodal medical image registration.

Journal: Medical & biological engineering & computing
Published Date:

Abstract

Medical image registration is a critical preprocessing step in medical image analysis. While traditional medical image registration techniques have matured, their registration speed and accuracy still fall short of clinical requirements. In this paper, we propose an improved VoxelMorph network incorporating ResNet modules and CBAM (RCV-Net), for 3D multimodal unsupervised registration. Unlike popular convolution-based U-shaped registration networks like VoxelMorph, RCV-Net incorporates the convolutional block attention module (CBAM) during the convolution process. This inclusion enhances the feature map information extraction capabilities during training and effectively prevents information loss. Additionally, we introduce a lightweight and residual network module at the network's base, which enhances learning ability without significantly increasing training parameters. To evaluate the superiority of our registration model, we utilize evaluation metrics such as structural similarity (SSIM), peak signal-to-noise ratio (PSNR), and mean square error (MSE). Experimental results demonstrate that our proposed network structure outperforms current state-of-the-art methods, yielding better performance in multimodal registration tasks. Furthermore, generalization testing on databases outside of the training set has confirmed the optimal registration effectiveness of our model.

Authors

  • Liwei Deng
    Heilongjiang Provincial Key Laboratory of Complex Intelligent System and Integration, School of Automation, Harbin University of Science and Technology, Harbin 150080, China.
  • Qi Lan
    Heilongjiang Provincial Key Laboratory of Complex Intelligent System and Integration, School of Automation, Harbin University of Science and Technology, Harbin, 150080, Heilongjiang, China.
  • Qiang Zhi
    Heilongjiang Provincial Key Laboratory of Complex Intelligent System and Integration, School of Automation, Harbin University of Science and Technology, Harbin, 150080, Heilongjiang, China.
  • Sijuan Huang
    Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, 510060, China.
  • Jing Wang
    Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing, China.
  • Xin Yang
    Department of Oral Maxillofacial-Head Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.