The 2022 Banff Meeting Lung Report.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Published Date: Nov 4, 2023

Abstract

The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed the state-of-the-art of current histopathologic entities, serologic studies, and molecular practices, as well as novel applications of digital pathology with artificial intelligence, gene expression analysis, and quantitative image analysis of chest computerized tomography. Current states of need as well as prospective integration of the aforementioned tools and technologies for complete assessment of allograft injury and its impact on lung transplant outcomes were discussed. Key conclusions from the discussion were: (1) recognition of limitations in current standard of care assessment of lung allograft dysfunction; (2) agreement on the need for a consensus regarding the standardized approach to the collection and assessment of pathologic data, inclusive of all lesions associated with graft outcome (eg, non-rejection pathology); and (3) optimism regarding promising novel diagnostic modalities, especially minimally invasive, which should be integrated into large, prospective multicenter studies to further evaluate their utility in clinical practice for directing personalized therapies to improve graft outcomes.

Authors

  • Elizabeth N Pavlisko
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: elizabeth.pavlisko@duke.edu.
  • Benjamin A Adam
    Department of Laboratory Medicine and Pathology, University of Alberta, 11405 87 Avenue NW, Edmonton, AB, T6G 1C9, Canada.
  • Gerald J Berry
    Department of Pathology, Stanford University, Stanford, California, USA.
  • Fiorella Calabrese
    Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua Medical School, Padua, Italy.
  • Nahir Cortes-Santiago
    Department of Pathology and Immunology, Texas Children's Hospital, Houston, Texas, USA.
  • Carolyn H Glass
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
  • Martin Goddard
    Pathology Department, Royal Papworth Hospital, NHS Trust, Papworth Everard, Cambridge, UK.
  • John R Greenland
    Department of Medicine, University of California, San Francisco, USA; Veterans Affairs Health Care System, San Francisco, California, USA.
  • Daniel Kreisel
    Department of Surgery, Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
  • Deborah J Levine
    Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, California, USA.
  • Tereza Martinu
    Division of Respirology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada; Toronto Lung Transplant Program, University Health Network, Toronto, Ontario, Canada.
  • Stijn E Verleden
    Lung Transplant Unit, Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium; Department of ASTARC, University of Antwerp, Wilrijk, Belgium.
  • S Sam Weigt
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of California Los Angeles, Los Angeles, California, USA.
  • Antoine Roux
    Department of Respiratory Medicine, Foch Hospital, Suresnes, France.

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