A Deep-Learning Algorithm to Predict Short-Term Progression to Geographic Atrophy on Spectral-Domain Optical Coherence Tomography.

Journal: JAMA ophthalmology
Published Date:

Abstract

IMPORTANCE: The identification of patients at risk of progressing from intermediate age-related macular degeneration (iAMD) to geographic atrophy (GA) is essential for clinical trials aimed at preventing disease progression. DeepGAze is a fully automated and accurate convolutional neural network-based deep learning algorithm for predicting progression from iAMD to GA within 1 year from spectral-domain optical coherence tomography (SD-OCT) scans.

Authors

  • Eliot R Dow
    Department of Ophthalmology, Byers Eye Institute at Stanford, Palo Alto, CA, USA.
  • Hyeon Ki Jeong
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 30308, USA.
  • Ella Arnon Katz
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
  • Cynthia A Toth
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
  • Dong Wang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
  • Terry Lee
    CIHR Canadian HIV Trials Network, Vancouver, British Columbia, Canada.
  • David Kuo
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
  • Michael J Allingham
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
  • Majda Hadziahmetovic
    Department of Ophthalmology, Duke University, Durham, NC, USA.
  • Priyatham S Mettu
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
  • Stefanie Schuman
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
  • Lawrence Carin
    Department of Electronic and Computer Engineering, Duke University, Durham, NC, 27705, USA.
  • Pearse A Keane
    National Institute for Health Research Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
  • Ricardo Henao
    Department of Electrical and Computer Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina.
  • Eleonora M Lad
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.