Machine Learning and CT Texture Features in Ex-smokers with no CT Evidence of Emphysema and Mildly Abnormal Diffusing Capacity.

Journal: Academic radiology
PMID: 38161089

Abstract

RATIONALE AND OBJECTIVES: Ex-smokers without spirometry or CT evidence of chronic obstructive pulmonary disease (COPD) but with mildly abnormal diffusing capacity of the lungs for carbon monoxide (DL) are at higher risk of developing COPD. It remains difficult to make clinical management decisions for such ex-smokers without other objective assessments consistent with COPD. Hence, our objective was to develop a machine-learning and CT texture-analysis pipeline to dichotomize ex-smokers with normal and abnormal DL (DL≥75% and DL<75%).

Authors

  • Maksym Sharma
    Robarts Research Institute, Western University, 1151 Richmond St N, London, N6A 5B7, Canada (M.S., G.P.); Department of Medical Biophysics, Western University, London, Canada (M.S., G.P.).
  • Miranda Kirby
    Department of Physics, Toronto Metropolitan University, Toronto, Canada (M.K.).
  • David G McCormack
    From the Robarts Research Institute, London, Canada (A.W., A.F., G.P.); Department of Medical Biophysics (A.W., A.D.W., A.F., G.P.), Division of Respirology, Department of Medicine (D.G.M., G.P.), and Department of Oncology (A.D.W.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; and Department of Radiation Oncology, Stanford University School of Medicine, Stanford, Calif (D.P.I.C.).
  • Grace Parraga
    From the Robarts Research Institute, London, Canada (A.W., A.F., G.P.); Department of Medical Biophysics (A.W., A.D.W., A.F., G.P.), Division of Respirology, Department of Medicine (D.G.M., G.P.), and Department of Oncology (A.D.W.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; and Department of Radiation Oncology, Stanford University School of Medicine, Stanford, Calif (D.P.I.C.).

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