Urinary exosomal viral microRNA as a marker of BK virus nephropathy in kidney transplant recipients.

Journal: PloS one
PMID: 29267352

Abstract

OBJECTIVE: Bkv-miR-B1-5p, one of the microRNAs encoded by BK virus, was recently reported to be elevated in the blood among the patients with BK virus nephropathy (BKVN). Urinary exosome was suggested to be a possible source of biomarker for kidney diseases, but it was unknown whether it could contain viral microRNA as well as human microRNAs. The aim of this study was to evaluate whether urinary exosomal BK viral microRNA were expressed during replication and could be used to diagnose BKVN in kidney transplant recipients.

Authors

  • Myeong Hee Kim
    Department of Laboratory Medicine, Kyung Hee University, Seoul, Korea.
  • Yu Ho Lee
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Jung-Woo Seo
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Haena Moon
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Jin Sug Kim
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Yang Gyun Kim
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Kyung-Hwan Jeong
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Ju-Young Moon
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Tae Won Lee
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Chun-Gyoo Ihm
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.
  • Chan-Duck Kim
    Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
  • Jae Berm Park
    Department of Surgery, Samsung Medical Center, Seoul, Korea.
  • Byung Ha Chung
  • Young-Hoon Kim
    Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • Sang-Ho Lee
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea.

Keywords

External Resources

Popular Topics
Recent Journals