AIMC Topic: Exosomes

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Identification of exosome-related genes in NSCLC via integrated bioinformatics and machine learning analysis.

Scientific reports
Exosomes are crucial in the development of non-small cell lung cancer (NSCLC), yet exosome-associated genes in NSCLC remain insufficiently explored. The present study identified 59 exosome-associated differentially expressed genes (EA-DEGs) from the ...

Novel exosome-associated LncRNA model predicts colorectal cancer prognosis and drug response.

Hereditas
BACKGROUND: Exosomes are extracellular vesicles that carry various biological substances and have potential as functional mediators in cancers. However, little is known about special molecules in colorectal cancer (CRC) exosomes and their immunologic...

Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study.

Gut
BACKGROUND AND OBJECTIVE: Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic methods are lacking. Exosome non-coding RNAs (ncRNAs), a type of liquid biopsy, have emerged as promising diagnostic biomarkers f...

Deep Learning-driven Microfluidic-SERS to Characterize the Heterogeneity in Exosomes for Classifying Non-Small Cell Lung Cancer Subtypes.

ACS sensors
Lung cancer exhibits strong heterogeneity, and its early diagnosis and precise subtyping are of great importance, as they can increase the ability to deliver personalized medicines by tailoring therapy regimens. Tissue biopsy, albeit the gold standar...

Cancer Cell Line Classification Using Raman Spectroscopy of Cancer-Derived Exosomes and Machine Learning.

Analytical chemistry
Liquid biopsies are an emerging, noninvasive tool for cancer diagnostics, utilizing biological fluids for molecular profiling. Nevertheless, the current methods often lack the sensitivity and specificity necessary for early detection and real-time mo...

Machine Learning-Based Identification of Novel Exosome-Derived Metabolic Biomarkers for the Diagnosis of Systemic Lupus Erythematosus and Differentiation of Renal Involvement.

Current medical science
OBJECTIVE: This study aims to investigate the exosome-derived metabolomicsĀ profiles in systemic lupus erythematosus (SLE), identify differential metabolites, and analyze their potential as diagnostic markers for SLE and lupus nephritis (LN).

Label-Free Exosomal SERS Detection Assisted by Machine Learning for Accurately Discriminating Cell Cycle Stages and Revealing the Molecular Mechanisms during the Mitotic Process.

Analytical chemistry
Cell cycle analysis is crucial for disease diagnosis and treatment, especially for investigating cell heterogeneity and regulating cell behaviors. Exosomes are highly appealing as noninvasive biomarkers for monitoring real-time changes in the cell cy...

ChatExosome: An Artificial Intelligence (AI) Agent Based on Deep Learning of Exosomes Spectroscopy for Hepatocellular Carcinoma (HCC) Diagnosis.

Analytical chemistry
Large language models (LLMs) hold significant promise in the field of medical diagnosis. There are still many challenges in the direct diagnosis of hepatocellular carcinoma (HCC). α-Fetoprotein (AFP) is a commonly used tumor marker for liver cancer. ...

Raman Spectroscopy and Exosome-Based Machine Learning Predicts the Efficacy of Neoadjuvant Therapy for HER2-Positive Breast Cancer.

Analytical chemistry
Early prediction of the neoadjuvant therapy efficacy for HER2-positive breast cancer is crucial for personalizing treatment and enhancing patient outcomes. Exosomes, which play a role in tumor development and treatment response, are emerging as poten...

A machine learning model revealed that exosome small RNAs may participate in the development of breast cancer through the chemokine signaling pathway.

BMC cancer
BACKGROUND: Exosome small RNAs are believed to be involved in the pathogenesis of cancer, but their role in breast cancer is still unclear. This study utilized machine learning models to screen for key exosome small RNAs and analyzed and validated th...